C₂₀H₂₃Cl₂FN₆O₂

Base Information

• Chemical Name: C₂₀H₂₃Cl₂FN₆O₂
• CAS No.: 1271808-06-0
• Molecular Formula: C₂₀H₂₃Cl₂FN₆O₂
• Molecular Weight: 469.346
• Mol file: 1271808-06-0.mol

Synonyms:

Chemical Property of C₂₀H₂₃Cl₂FN₆O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₃Cl₂FN₆O₂

There total 7 articles about C₂₀H₂₃Cl₂FN₆O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 6-methylidene-1,4-oxazepan-4-carboxylate (748805-96-1) → C20H23Cl2FN6O2 (1271808-06-0)

Guidance literature:

Multi-step reaction with 7 steps

1: osmium(VIII) oxide; sodium periodate / 1,4-dioxane; water; tert-butyl alcohol / 18 h / 20 °C

2: hydroxylamine hydrochloride; triethylamine / tetrahydrofuran / 20 °C

3: hydrogen; hydrogen bromide / water; methanol / 144 h / 20 °C / 3206.4 Torr

4: triethylamine / Cooling with ice

5: sodium hydride / tetrahydrofuran; mineral oil / 7 h / 65 °C / Cooling with ice

6: chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; iodine / toluene

7: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; sodium periodate; osmium(VIII) oxide; chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; hydroxylamine hydrochloride; hydrogen bromide; hydrogen; iodine; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene; mineral oil; tert-butyl alcohol;

Reference yield:

6-oxo-[1,4]oxazepane-4-carboxylic acid tert-butyl ester (748805-97-2) → C20H23Cl2FN6O2 (1271808-06-0)

Guidance literature:

Multi-step reaction with 6 steps

1: hydroxylamine hydrochloride; triethylamine / tetrahydrofuran / 20 °C

2: hydrogen; hydrogen bromide / water; methanol / 144 h / 20 °C / 3206.4 Torr

3: triethylamine / Cooling with ice

4: sodium hydride / tetrahydrofuran; mineral oil / 7 h / 65 °C / Cooling with ice

5: chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; iodine / toluene

6: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; hydroxylamine hydrochloride; hydrogen bromide; hydrogen; iodine; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene; mineral oil;

Reference yield:

tert-butyl 6-amino-1,4-oxazepane-4-carboxylate (1170390-54-1) → C20H23Cl2FN6O2 (1271808-06-0)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / Cooling with ice

2: sodium hydride / tetrahydrofuran; mineral oil / 7 h / 65 °C / Cooling with ice

3: chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; iodine / toluene

4: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; iodine; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; toluene; mineral oil;

upstream raw materials:

tert-butyl 6-methylidene-1,4-oxazepan-4-carboxylate

6-oxo-[1,4]oxazepane-4-carboxylic acid tert-butyl ester

6-chloro-5-fluoropyrimidin-4-ylamine

C₂₁H₂₉Cl₂N₃O₄