1-tert-butyl-5-(4-methoxyphenethyl)-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:1-tert-butyl-5-(4-methoxyphenethyl)-1H-pyrazole-4-carboxamide
CAS No.:1421849-48-0
Molecular Formula:C₁₇H₂₃N₃O₂
Molecular Weight:301.389
Hs Code.:

Synonyms:

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Chemical Property of 1-tert-butyl-5-(4-methoxyphenethyl)-1H-pyrazole-4-carboxamide

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Technology Process of 1-tert-butyl-5-(4-methoxyphenethyl)-1H-pyrazole-4-carboxamide

There total 4 articles about 1-tert-butyl-5-(4-methoxyphenethyl)-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112779-14-3
1-(tert-butyl)-5-amino-pyrazole-4-carboxylic acid ethyl ester

: 1421849-48-0
1-tert-butyl-5-(4-methoxyphenethyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: n-Amyl nitrite; copper(ll) bromide / acetonitrile / 4 h / 20 °C

2: sodium hydroxide; water / ethanol; tetrahydrofuran / 2.5 h / 60 °C

3: ammonium chloride; benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; water / 14 h / 20 °C

4: potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / tetrahydrofuran / 14 h / 40 °C / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 6 h / 20 °C / 760.05 Torr

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; n-Amyl nitrite; palladium 10% on activated carbon; water; hydrogen; palladium diacetate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; copper(ll) bromide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 98534-79-3
5-bromo-1-tert-butyl-1H-pyrazole-4-carboxylic acid

: 1421849-48-0
1-tert-butyl-5-(4-methoxyphenethyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium chloride; benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; water / 14 h / 20 °C

2: potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / tetrahydrofuran / 14 h / 40 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 6 h / 20 °C / 760.05 Torr

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium 10% on activated carbon; hydrogen; palladium diacetate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1245272-40-5
ethyl 5-bromo-1-tert-butyl-1H-pyrazole-4-carboxylate

: 1421849-48-0
1-tert-butyl-5-(4-methoxyphenethyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; water / ethanol; tetrahydrofuran / 2.5 h / 60 °C

2: ammonium chloride; benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; water / 14 h / 20 °C

3: potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / tetrahydrofuran / 14 h / 40 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 6 h / 20 °C / 760.05 Torr

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium 10% on activated carbon; water; hydrogen; palladium diacetate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;