Physcionin

Base Information

• Chemical Name: Physcionin
• CAS No.: 23451-01-6
• Molecular Formula: C₂₂H₂₂O₁₀
• Molecular Weight: 446.411
• Wikidata: Q104399470
• Mol file: 23451-01-6.mol

Synonyms:Physcionin;1-hydroxy-6-methoxy-3-methyl-8-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyanthracene-9,10-dione;Physcion 8-beta-D-glucoside;SCHEMBL23366483;CHEBI:191707;Physcion-8-O-EC-D-glucopyranoside;B0005-464836

Chemical Property of Physcionin

Chemical Property:

• Melting Point: 235 °C(Solv: methanol (67-56-1))
• Boiling Point: 796.3±60.0 °C(Predicted)
• PKA: 6.59±0.20(Predicted)
• Density: 1.567±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly)
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 4
• Exact Mass: 446.12129689
• Heavy Atom Count: 32
• Complexity: 715

Purity/Quality:

99% ^*data from raw suppliers

Physcion8-β-D-glucoside ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3OC4C(C(C(C(O4)CO)O)O)O)OC
• Uses: Physcion 8-β-D-glucoside has been studied in research relating to the treatment of the glomerulonephritis. It is the glucoside of Physcion (P398000) which is a natural anthraquinone derivative, on the infection process of Blumeria graminis on wheat. Physcion is one of the important active ingredients of ethanol extract from the roots of Chinese rhubarb (Rheum officinale) for controlling powdery mi ldew. Physcion 8-β-D-glucoside has been studied in research relating to the treatment of the glomerulonephritis. It is the glucoside of Physcion (P398000) which is a natural anthraquinone derivative, on the infection process of Blumeria graminis on wheat. Physcion is one of the important active ingredients of ethanol extract from the roots of Chinese rhubarb (Rheum officinale) for controlling powdery mildew.

Technology Process of Physcionin

There total 3 articles about Physcionin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

physcion-8-O-β-primeveroside → physcion 8-O-β-D-glucopyranoside (23451-01-6,75721-38-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 10 percent H₂SO₄ / 1 h / Heating

With sulfuric acid;

DOI:10.1016/S0031-9422(00)80491-4

Reference yield:

physcion (521-61-9) + 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (572-09-8) → physcion 8-O-β-D-glucopyranoside (23451-01-6,75721-38-9)

Guidance literature:

DOI:10.1016/S0031-9422(00)80491-4

Reference yield:

→ Physcionin (23451-01-6,75721-38-9)

Guidance literature:

1-(oder 8)-O-(Tetraacetyl-β-D-glucosyl)-8-(oder 1)-hydroxy-6-methoxy-3-methylanthrachinon, MeOH, 1percentig.wss.NaOH, Siedetemp., 5 Min.;

upstream raw materials:

physcion

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide