(Z)-(2R,4R,6S,9R,13R)-14-Dimethylaminomethyl-2,10-dimethoxy-6-(4-methoxy-benzyloxy)-5,5,9-trimethyl-tricyclo[11.2.1.0^4,9]hexadeca-1⁽¹⁶⁾,10-dien-15-one

Base Information

• Chemical Name: (Z)-(2R,4R,6S,9R,13R)-14-Dimethylaminomethyl-2,10-dimethoxy-6-(4-methoxy-benzyloxy)-5,5,9-trimethyl-tricyclo[11.2.1.0^4,9]hexadeca-1⁽¹⁶⁾,10-dien-15-one
• CAS No.: 186087-66-1
• Molecular Formula: C₃₂H₄₇NO₅
• Molecular Weight: 525.729

Synonyms:

Chemical Property of (Z)-(2R,4R,6S,9R,13R)-14-Dimethylaminomethyl-2,10-dimethoxy-6-(4-methoxy-benzyloxy)-5,5,9-trimethyl-tricyclo[11.2.1.0^4,9]hexadeca-1⁽¹⁶⁾,10-dien-15-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-(2R,4R,6S,9R,13R)-14-Dimethylaminomethyl-2,10-dimethoxy-6-(4-methoxy-benzyloxy)-5,5,9-trimethyl-tricyclo[11.2.1.0^4,9]hexadeca-1⁽¹⁶⁾,10-dien-15-one

There total 13 articles about (Z)-(2R,4R,6S,9R,13R)-14-Dimethylaminomethyl-2,10-dimethoxy-6-(4-methoxy-benzyloxy)-5,5,9-trimethyl-tricyclo[11.2.1.0^4,9]hexadeca-1⁽¹⁶⁾,10-dien-15-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-(2R,4R,6S,9R,13S)-2,10-Dimethoxy-6-(4-methoxy-benzyloxy)-5,5,9-trimethyl-tricyclo[11.2.1.04,9]hexadeca-1(16),10-dien-15-one (186087-64-9) → (Z)-(2R,4R,6S,9R,13R)-14-Dimethylaminomethyl-2,10-dimethoxy-6-(4-methoxy-benzyloxy)-5,5,9-trimethyl-tricyclo[11.2.1.04,9]hexadeca-1(16),10-dien-15-one (186087-66-1)

Guidance literature:

Multi-step reaction with 2 steps

1: LDA / tetrahydrofuran / 2 h / -78 °C

2: dimethylformamide / 50 °C

With lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(96)02247-2

Reference yield:

(1R,3'R,4'aR,5R,6'S,8'aR)-3',4',4'a,5',6',7',8',8'a-octahydro-3'-methoxy-6'-[(p-methoxybenzyl)oxy]-5',5',8'a-trimethyl-5-[2-(trimethylsilyl)ethoxy]spiro[2-cyclopentene-1,2'(1'H)-naphthalene]-1'-one (184637-36-3) → (Z)-(2R,4R,6S,9R,13R)-14-Dimethylaminomethyl-2,10-dimethoxy-6-(4-methoxy-benzyloxy)-5,5,9-trimethyl-tricyclo[11.2.1.04,9]hexadeca-1(16),10-dien-15-one (186087-66-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 96 percent / tetrahydrofuran

2: 97 percent / tetrahydrofuran

3: 58 percent / 1.) DMF; 2.) CsF, DMF / 210 °C / 1.) 4.5 h; 2.) 6.5 h

4: 100 percent / periodinane / CH₂Cl₂

5: LDA / tetrahydrofuran / 2 h / -78 °C

6: dimethylformamide / 50 °C

With Dess-Martin periodane; N,N-dimethyl-formamide; cesium fluoride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(96)02247-2

Reference yield:

C32H48O5Si (186087-72-9) → (Z)-(2R,4R,6S,9R,13R)-14-Dimethylaminomethyl-2,10-dimethoxy-6-(4-methoxy-benzyloxy)-5,5,9-trimethyl-tricyclo[11.2.1.04,9]hexadeca-1(16),10-dien-15-one (186087-66-1)

Guidance literature:

Multi-step reaction with 6 steps

1: LiAlH₄

2: 80 percent / NaH / tetrahydrofuran

3: 25 percent / 1.) DMF; 2.) CsF, DMF / 210 °C

4: 84 percent / periodinane / CH₂Cl₂

5: LDA / tetrahydrofuran / 2 h / -78 °C

6: dimethylformamide / 50 °C

With lithium aluminium tetrahydride; sodium hydride; Dess-Martin periodane; N,N-dimethyl-formamide; cesium fluoride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(96)02247-2

upstream raw materials:

eschenmoser's salt

[(Z)-(2R,4R,6S,9R,13R)-2,10-Dimethoxy-6-(4-methoxy-benzyloxy)-5,5,9-trimethyl-tricyclo[11.2.1.0^4,9]hexadeca-1⁽¹⁶⁾,10,14-trien-15-yloxy]-trimethyl-silane

(Z)-(2R,4R,6S,9R,13S)-2,10-Dimethoxy-6-(4-methoxy-benzyloxy)-5,5,9-trimethyl-tricyclo[11.2.1.0^4,9]hexadeca-1⁽¹⁶⁾,10-dien-15-one

(1R,3'R,4'aR,5R,6'S,8'aR)-3',4',4'a,5',6',7',8',8'a-octahydro-3'-methoxy-6'-[(p-methoxybenzyl)oxy]-5',5',8'a-trimethyl-5-[2-(trimethylsilyl)ethoxy]spiro[2-cyclopentene-1,2'(1'H)-naphthalene]-1'-one

Downstream raw materials:

(Z)-(2R,4R,6S,9R,13R)-2,10-Dimethoxy-6-(4-methoxy-benzyloxy)-5,5,9-trimethyl-14-methylene-tricyclo[11.2.1.0^4,9]hexadeca-1⁽¹⁶⁾,10-dien-15-one

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