Technology Process of (1R,6RS,8R)-6-(benzyloxy)bicyclo[6.1.0]nonan-2-one (2S,3S)-1,4-di-O-methyl-1,2,3,4-butanetetrol ketal
There total 5 articles about (1R,6RS,8R)-6-(benzyloxy)bicyclo[6.1.0]nonan-2-one (2S,3S)-1,4-di-O-methyl-1,2,3,4-butanetetrol ketal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 76 percent / TsOH / benzene / 3 h / Heating
2: 97 percent / phenyltrimethylammonium tribromide / tetrahydrofuran / 17 h / Ambient temperature
3: 86 percent / sodium methoxide / dimethylsulfoxide / 72 h / Ambient temperature
4: 1.) Zn(Cu), iodine / 1.) ether, reflux, 2 h, 2.) ether, reflux, 18 h
With
zinc copper; iodine; sodium methylate; phenyltrimethylammonium tribromide; toluene-4-sulfonic acid;
In
tetrahydrofuran; dimethyl sulfoxide; benzene;
DOI:10.1016/S0040-4020(97)00615-7
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 76 percent / TsOH / benzene / 3 h / Heating
2: 97 percent / phenyltrimethylammonium tribromide / tetrahydrofuran / 17 h / Ambient temperature
3: 86 percent / sodium methoxide / dimethylsulfoxide / 72 h / Ambient temperature
4: 1.) Zn(Cu), iodine / 1.) ether, reflux, 2 h, 2.) ether, reflux, 18 h
With
zinc copper; iodine; sodium methylate; phenyltrimethylammonium tribromide; toluene-4-sulfonic acid;
In
tetrahydrofuran; dimethyl sulfoxide; benzene;
DOI:10.1016/S0040-4020(97)00615-7
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 97 percent / phenyltrimethylammonium tribromide / tetrahydrofuran / 17 h / Ambient temperature
2: 86 percent / sodium methoxide / dimethylsulfoxide / 72 h / Ambient temperature
3: 1.) Zn(Cu), iodine / 1.) ether, reflux, 2 h, 2.) ether, reflux, 18 h
With
zinc copper; iodine; sodium methylate; phenyltrimethylammonium tribromide;
In
tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(97)00615-7
