N-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl]-2,2,2-trifluoro-acetamide

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Chemical Name:N-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl]-2,2,2-trifluoro-acetamide
CAS No.:118849-19-7
Molecular Formula:C₃₂H₃₀F₃N₃O₈
Molecular Weight:641.601
Hs Code.:

<i>N</i>-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl]-2,2,2-trifluoro-acetamide

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Chemical Property of N-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl]-2,2,2-trifluoro-acetamide

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Technology Process of N-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl]-2,2,2-trifluoro-acetamide

There total 11 articles about N-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl]-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58-96-8
uridine

: 118849-19-7
N-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 10 steps

1: 90 percent

2: triethylamine / CH₂Cl₂ / 0.5 h / 20 °C

3: CH₂Cl₂ / 2 h / 20 °C

4: 3.5 g / p-toluenesulfonic acid / CH₂Cl₂; dioxane / 0.03 h / 20 °C

5: 70 percent / triphenylphosphine; diethyl azodicarboxylate; diphenyl azidophosphate

6: aq. NH₃

7: n-Bu₄NF

8: 1.65 g

9: triphenylphosphine

With ammonium hydroxide; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; dichloromethane; 1: Cyclization / 2: silylation / 3: Acylation / 4: desilylation / 5: Mitsunobu reaction / 6: Hydrolysis / 7: Ring cleavage / 8: Etherification / 9: Staudinger reaction / 10: Acylation;

Reference yield:

: 1-((2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-trimethylsilanyloxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-4-trimethylsilanyloxy-1H-pyrimidin-2-one

: 118849-19-7
N-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: CH₂Cl₂ / 2 h / 20 °C

2: 3.5 g / p-toluenesulfonic acid / CH₂Cl₂; dioxane / 0.03 h / 20 °C

3: 70 percent / triphenylphosphine; diethyl azodicarboxylate; diphenyl azidophosphate

4: aq. NH₃

5: n-Bu₄NF

6: 1.65 g

7: triphenylphosphine

With ammonium hydroxide; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; dichloromethane; 1: Acylation / 2: desilylation / 3: Mitsunobu reaction / 4: Hydrolysis / 5: Ring cleavage / 6: Etherification / 7: Staudinger reaction / 8: Acylation;

Reference yield:

: 3-Benzoyl-1-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-trimethylsilanyloxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione

: 118849-19-7
N-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 3.5 g / p-toluenesulfonic acid / CH₂Cl₂; dioxane / 0.03 h / 20 °C

2: 70 percent / triphenylphosphine; diethyl azodicarboxylate; diphenyl azidophosphate

3: aq. NH₃

4: n-Bu₄NF

5: 1.65 g

6: triphenylphosphine

With ammonium hydroxide; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; dichloromethane; 1: desilylation / 2: Mitsunobu reaction / 3: Hydrolysis / 4: Ring cleavage / 5: Etherification / 6: Staudinger reaction / 7: Acylation;