butyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate

Base Information

• Chemical Name: butyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate
• CAS No.: 1214284-58-8
• Molecular Formula: C₃₀H₃₉ClN₄O₆
• Molecular Weight: 587.116
• Mol file: 1214284-58-8.mol

Synonyms:

Chemical Property of butyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of butyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate

There total 1 articles about butyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

butyl (S)-4-(2-amino-4-tert-butoxycarbonylbutyryl)piperazine-1-carboxylate (1019929-10-2) + 4-chloro-6-phenylpyridine-2-carboxylic acid (85814-96-6) → butyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate (1214284-58-8)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; for 16h;

DOI:10.1021/jm901518t

Reference yield:

butyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate (1214284-58-8) + 4-(N,N-diethylaminomethyl)piperidine (116905-90-9) → C40H60N6O6

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 100 ℃;

DOI:10.1016/j.bmcl.2009.12.110

Reference yield:

butyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate (1214284-58-8) + 4-(2-oxo-pyrrolidin-1-ylmethyl)-piperidine (139726-90-2) → C40H56N6O7

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 100 ℃;

DOI:10.1016/j.bmcl.2009.12.110

upstream raw materials:

butyl (S)-4-(2-amino-4-tert-butoxycarbonylbutyryl)piperazine-1-carboxylate

4-chloro-6-phenylpyridine-2-carboxylic acid

Downstream raw materials:

C₃₆H₄₉N₅O₈