C₁₉H₂₆Cl⁽¹⁸⁾FN₂O

Base Information

• Chemical Name: C₁₉H₂₆Cl⁽¹⁸⁾FN₂O
• CAS No.: 1384179-52-5
• Molecular Formula: C₁₉H₂₆ClFN₂O
• Molecular Weight: 351.881
• Mol file: 1384179-52-5.mol

Synonyms:

Chemical Property of C₁₉H₂₆Cl⁽¹⁸⁾FN₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₆Cl⁽¹⁸⁾FN₂O

There total 3 articles about C₁₉H₂₆Cl⁽¹⁸⁾FN₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H26Cl2N2O (1384179-44-5) → C19H26Cl(18)FN2O (1384179-52-5)

Guidance literature:

With [18F]fluoride ion; potassium carbonate; [2.2.2]cryptande; In dimethyl sulfoxide; at 110 ℃; for 0.166667h;

DOI:10.1016/j.bmcl.2012.05.030

Reference yield:

C18H23Cl2NO2 (1384179-36-5) → C19H26Cl(18)FN2O (1384179-52-5)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride; water / 12 h / Reflux

2: oxalyl dichloride / dichloromethane / 4 h / 20 °C

3: dichloromethane / 8 h / 20 °C

4: [18F]fluoride ion; potassium carbonate; [2.2.2]cryptande / dimethyl sulfoxide / 0.17 h / 110 °C

With hydrogenchloride; oxalyl dichloride; [18F]fluoride ion; water; potassium carbonate; [2.2.2]cryptande; In dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2012.05.030

Reference yield:

C17H21Cl2NO2 (1384179-38-7) → C19H26Cl(18)FN2O (1384179-52-5)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride / dichloromethane / 4 h / 20 °C

2: dichloromethane / 8 h / 20 °C

3: [18F]fluoride ion; potassium carbonate; [2.2.2]cryptande / dimethyl sulfoxide / 0.17 h / 110 °C

With oxalyl dichloride; [18F]fluoride ion; potassium carbonate; [2.2.2]cryptande; In dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2012.05.030

upstream raw materials:

C₁₈H₂₃Cl₂NO₂

C₁₇H₂₁Cl₂NO₂

C₁₉H₂₆Cl₂N₂O