(8-Acetyl-2,4-bis-benzyloxy-7,8-dihydro-pteridin-6-yl)-[1-acetyl-6-bromo-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid 2-methylsulfanyl-ethyl ester

Base Information

• Chemical Name: (8-Acetyl-2,4-bis-benzyloxy-7,8-dihydro-pteridin-6-yl)-[1-acetyl-6-bromo-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid 2-methylsulfanyl-ethyl ester
• CAS No.: 94779-76-7
• Molecular Formula: C₃₇H₃₂BrN₅O₇S
• Molecular Weight: 770.66

Synonyms:

Chemical Property of (8-Acetyl-2,4-bis-benzyloxy-7,8-dihydro-pteridin-6-yl)-[1-acetyl-6-bromo-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid 2-methylsulfanyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (8-Acetyl-2,4-bis-benzyloxy-7,8-dihydro-pteridin-6-yl)-[1-acetyl-6-bromo-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid 2-methylsulfanyl-ethyl ester

There total 12 articles about (8-Acetyl-2,4-bis-benzyloxy-7,8-dihydro-pteridin-6-yl)-[1-acetyl-6-bromo-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid 2-methylsulfanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

acetic anhydride (108-24-7) + 2-(methylthio)ethyl 6-bromo-α-<7,8-dihydro-2,4-bis(phenylmethoxy)-6(5H)-pteridinylidene>-2,3-dihydro-2-oxo-1H-indole-3-acetate (158320-59-3) → (8-Acetyl-2,4-bis-benzyloxy-7,8-dihydro-pteridin-6-yl)-[1-acetyl-6-bromo-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid 2-methylsulfanyl-ethyl ester (94779-76-7,94779-77-8) + [1-Acetyl-6-bromo-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-(2,4-bis-benzyloxy-pteridin-6-yl)-acetic acid 2-methylsulfanyl-ethyl ester + [8-Acetyl-2,4-bis-benzyloxy-7,8-dihydro-5H-pteridin-(6E)-ylidene]-(1-acetyl-6-bromo-2-oxo-2,3-dihydro-1H-indol-3-yl)-acetic acid 2-methylsulfanyl-ethyl ester (158320-61-7)

Guidance literature:

With pyridine; at 70 ℃; for 2h;

DOI:10.1016/S0040-4020(01)86989-1

Reference yield:

6-bromoisatin (6326-79-0) → (8-Acetyl-2,4-bis-benzyloxy-7,8-dihydro-pteridin-6-yl)-[1-acetyl-6-bromo-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid 2-methylsulfanyl-ethyl ester (94779-76-7,94779-77-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 82 percent / piperidine, acetic acid / benzene / 5 h / Heating

2: 92 percent / Na₂S₂O₄ / ethanol; H₂O / 0.08 h / Heating

3: 27 percent / NH₂NH₂*H₂O / CH₂Cl₂; methanol / 0.5 h

4: 90 percent / NaHCO₃ / dimethylformamide / 1 h / Ambient temperature

5: 94 percent / Zn, AcOH / tetrahydrofuran / 10 h / 0 °C

6: 50 percent / pyridine / 2 h / 70 °C

With piperidine; pyridine; sodium dithionite; sodium hydrogencarbonate; hydrazine hydrate; acetic acid; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;

DOI:10.1016/S0040-4020(01)86989-1

Reference yield:

2-(methylthio)ethyl 6-bromo-α-<(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl>-2,3-dihydro-2-oxo-1H-indole-3-acetate (94779-72-3) → (8-Acetyl-2,4-bis-benzyloxy-7,8-dihydro-pteridin-6-yl)-[1-acetyl-6-bromo-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid 2-methylsulfanyl-ethyl ester (94779-76-7,94779-77-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 27 percent / NH₂NH₂*H₂O / CH₂Cl₂; methanol / 0.5 h

2: 90 percent / NaHCO₃ / dimethylformamide / 1 h / Ambient temperature

3: 94 percent / Zn, AcOH / tetrahydrofuran / 10 h / 0 °C

4: 50 percent / pyridine / 2 h / 70 °C

With pyridine; sodium hydrogencarbonate; hydrazine hydrate; acetic acid; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)86989-1

upstream raw materials:

acetic anhydride

2-(methylthio)ethyl 6-bromo-2,3-dihydro-α-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>acetyl>-2-oxo-1H-indole-3-acetate

2-(methylthio)ethyl 6-bromo-α-<7,8-dihydro-2,4-bis(phenylmethoxy)-6(5H)-pteridinylidene>-2,3-dihydro-2-oxo-1H-indole-3-acetate

6-bromoisatin

Downstream raw materials:

2-(methylthio)ethyl 8-acetyl-α-(1-acetyl-6-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-5,6,7,8-tetrahydro-2,4-bis(phenylmethoxy)-6-pteridineacetate

2-(methylthio)ethyl 8-acetyl-α-(1-acetyl-6-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-5,6,7,8-tetrahydro-2,4-bis(phenylmethoxy)-6-pteridineacetate

C₂₅H₂₄BrN₅O₁₂

2-(methylthio)ethyl 1,5'-diacetyl-6-bromo-1,2,5',6',9',10'-hexahydro-9'-hydroxy-9'-methyl-2,10'-dioxo-1',3'-bis(phenylmethoxy)spiro<3H-indole-3,8'-<8H>pyrido<1,2-f>pteridine>-7'-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 94779-76-7 (8-Acetyl-2,4-bis-benzyloxy-7,8-dihydro-pteridin-6-yl)-[1-acetyl-6-bromo-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid 2-methylsulfanyl-ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send