(2R,4S)-2-[(5aR,6R,8aR)-6-((R)-1,5-Dimethyl-hexyl)-5a-methyl-5,5a,6,7,8,8a-hexahydro-4H-indeno[5,4-b]thiophen-2-yl]-4-hydroxy-2-methyl-cyclohexanone

Base Information

Chemical Name:(2R,4S)-2-[(5aR,6R,8aR)-6-((R)-1,5-Dimethyl-hexyl)-5a-methyl-5,5a,6,7,8,8a-hexahydro-4H-indeno[5,4-b]thiophen-2-yl]-4-hydroxy-2-methyl-cyclohexanone
CAS No.:105804-45-3
Molecular Formula:C₂₇H₄₂O₂S
Molecular Weight:430.695
Hs Code.:

(2R,4S)-2-[(5aR,6R,8aR)-6-((R)-1,5-Dimethyl-hexyl)-5a-methyl-5,5a,6,7,8,8a-hexahydro-4H-indeno[5,4-b]thiophen-2-yl]-4-hydroxy-2-methyl-cyclohexanone

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Chemical Property of (2R,4S)-2-[(5aR,6R,8aR)-6-((R)-1,5-Dimethyl-hexyl)-5a-methyl-5,5a,6,7,8,8a-hexahydro-4H-indeno[5,4-b]thiophen-2-yl]-4-hydroxy-2-methyl-cyclohexanone

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Technology Process of (2R,4S)-2-[(5aR,6R,8aR)-6-((R)-1,5-Dimethyl-hexyl)-5a-methyl-5,5a,6,7,8,8a-hexahydro-4H-indeno[5,4-b]thiophen-2-yl]-4-hydroxy-2-methyl-cyclohexanone

There total 3 articles about (2R,4S)-2-[(5aR,6R,8aR)-6-((R)-1,5-Dimethyl-hexyl)-5a-methyl-5,5a,6,7,8,8a-hexahydro-4H-indeno[5,4-b]thiophen-2-yl]-4-hydroxy-2-methyl-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105804-44-2,105817-41-2
Acetic acid (1S,3R)-3-[(5aR,6R,8aR)-6-((R)-1,5-dimethyl-hexyl)-5a-methyl-5,5a,6,7,8,8a-hexahydro-4H-indeno[5,4-b]thiophen-2-yl]-3-methyl-4-oxo-cyclohexyl ester

: 105804-45-3
(2R,4S)-2-[(5aR,6R,8aR)-6-((R)-1,5-Dimethyl-hexyl)-5a-methyl-5,5a,6,7,8,8a-hexahydro-4H-indeno[5,4-b]thiophen-2-yl]-4-hydroxy-2-methyl-cyclohexanone

Guidance literature:: With potassium hydroxide; In ethanol; water; at 40 ℃; for 1h;
DOI:10.1139/v86-252

Reference yield:

: 17756-93-3
3β-acetoxy-5-methyl-19-nor-5β-cholest-9(10)-en-6-one

: 105804-45-3
(2R,4S)-2-[(5aR,6R,8aR)-6-((R)-1,5-Dimethyl-hexyl)-5a-methyl-5,5a,6,7,8,8a-hexahydro-4H-indeno[5,4-b]thiophen-2-yl]-4-hydroxy-2-methyl-cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) O₃, 2.) Zn / 1.) hexane, -70 deg C, 2.) AcOH, 45 min, room temp.

2: 62 percent / phosphorus pentasulfide, potassium hydrogen carbonate / tetrahydrofuran / 1 h / Heating

3: potassium hydroxyde / H₂O; ethanol / 1 h / 40 °C

With diphosphorus pentasulfide; potassium hydroxide; potassium hydrogencarbonate; ozone; zinc; In tetrahydrofuran; ethanol; water;
DOI:10.1139/v86-252

Reference yield:

: 105804-43-1
Acetic acid (1S,3R)-3-{2-[(1R,3aS,4S,7aR)-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-5-oxo-octahydro-inden-4-yl]-acetyl}-3-methyl-4-oxo-cyclohexyl ester

: 105804-45-3
(2R,4S)-2-[(5aR,6R,8aR)-6-((R)-1,5-Dimethyl-hexyl)-5a-methyl-5,5a,6,7,8,8a-hexahydro-4H-indeno[5,4-b]thiophen-2-yl]-4-hydroxy-2-methyl-cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / phosphorus pentasulfide, potassium hydrogen carbonate / tetrahydrofuran / 1 h / Heating

2: potassium hydroxyde / H₂O; ethanol / 1 h / 40 °C

With diphosphorus pentasulfide; potassium hydroxide; potassium hydrogencarbonate; In tetrahydrofuran; ethanol; water;
DOI:10.1139/v86-252