7-Chloro-1,3,4,10-tetrahydro-10-hydroxy-1-[[3-(1-piperidinyl)propyl]imino]-3-(3,4,5-trimethoxyphenyl)-9(2H)-acridinone

Base Information

Chemical Name:7-Chloro-1,3,4,10-tetrahydro-10-hydroxy-1-[[3-(1-piperidinyl)propyl]imino]-3-(3,4,5-trimethoxyphenyl)-9(2H)-acridinone
CAS No.:144154-86-9
Molecular Formula:C₃₀H₃₆ClN₃O₅
Molecular Weight:554.086
Hs Code.:
DSSTox Substance ID:DTXSID101105797
ChEMBL ID:CHEMBL117882

Synonyms:CHEMBL117882;DTXSID101105797;(1Z)-7-Chloro-10-hydroxy-1-([(Z)-3-(1-piperidinyl)propyl]imino)-3-(3,4,5-trimethoxyphenyl)-1,3,4,10-tetrahydro-9(2H)-acridinone #;144154-86-9;7-Chloro-1,3,4,10-tetrahydro-10-hydroxy-1-[[3-(1-piperidinyl)propyl]imino]-3-(3,4,5-trimethoxyphenyl)-9(2H)-acridinone;7-Chloro-1,3,4,10-tetrahydro-10-hydroxy-1-[[3-[1-piperidinyl]propyl]imino]-3-[3,4,5(trimethoxy)phenyl]-9(2H)-acridinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-Chloro-1,3,4,10-tetrahydro-10-hydroxy-1-[[3-(1-piperidinyl)propyl]imino]-3-(3,4,5-trimethoxyphenyl)-9(2H)-acridinone

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:553.2343490
Heavy Atom Count:39
Complexity:908

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)C2CC3=C(C(=NCCCN4CCCCC4)C2)C(=O)C5=C(N3O)C=CC(=C5)Cl

Technology Process of 7-Chloro-1,3,4,10-tetrahydro-10-hydroxy-1-[[3-(1-piperidinyl)propyl]imino]-3-(3,4,5-trimethoxyphenyl)-9(2H)-acridinone

There total 6 articles about 7-Chloro-1,3,4,10-tetrahydro-10-hydroxy-1-[[3-(1-piperidinyl)propyl]imino]-3-(3,4,5-trimethoxyphenyl)-9(2H)-acridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 3529-08-6
1-(3-aminopropyl)piperidine

: 144128-88-1
7-Chloro-10-hydroxy-3-(3,4,5-trimethoxy-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione

: 144154-86-9
7-Chloro-10-hydroxy-1-[(E)-3-piperidin-1-yl-propylimino]-3-(3,4,5-trimethoxy-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one

Guidance literature:: In benzene; for 2h; Heating;
DOI:10.1021/jm00097a001

Reference yield:

: 10421-02-0
4-(3,4,5-trimethoxyphenyl)-3-buten-2-one

: 144154-86-9
7-Chloro-10-hydroxy-1-[(E)-3-piperidin-1-yl-propylimino]-3-(3,4,5-trimethoxy-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one

Guidance literature:: Multi-step reaction with 5 steps

1: EtONa / ethanol / 6 h / Heating

2: 2 N NaOH / 2 h / Heating

3: 5 N H₂SO₄ / 4.5 h / Heating

4: 29 percent / concd HCl, glacial AcOH / 4 h / 85 °C

5: 43 percent / benzene / 2 h / Heating

With hydrogenchloride; sodium hydroxide; sulfuric acid; sodium ethanolate; acetic acid; In ethanol; benzene;
DOI:10.1021/jm00097a001

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 144154-86-9
7-Chloro-10-hydroxy-1-[(E)-3-piperidin-1-yl-propylimino]-3-(3,4,5-trimethoxy-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / 50percent aq. NaOH / 72 h / Ambient temperature

2: EtONa / ethanol / 6 h / Heating

3: 2 N NaOH / 2 h / Heating

4: 5 N H₂SO₄ / 4.5 h / Heating

5: 29 percent / concd HCl, glacial AcOH / 4 h / 85 °C

6: 43 percent / benzene / 2 h / Heating

With hydrogenchloride; sodium hydroxide; sulfuric acid; sodium ethanolate; acetic acid; In ethanol; benzene;
DOI:10.1021/jm00097a001