2-(trimethylsilyl)ethyl 2-O-benzyl-3,4-O-(ethyl orthoacetyl)-β-L-fucopyranoside

Base Information

Chemical Name:2-(trimethylsilyl)ethyl 2-O-benzyl-3,4-O-(ethyl orthoacetyl)-β-L-fucopyranoside
CAS No.:124488-73-9
Molecular Formula:C₂₂H₃₆O₆Si
Molecular Weight:424.61
Hs Code.:

Synonyms:

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Chemical Property of 2-(trimethylsilyl)ethyl 2-O-benzyl-3,4-O-(ethyl orthoacetyl)-β-L-fucopyranoside

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Technology Process of 2-(trimethylsilyl)ethyl 2-O-benzyl-3,4-O-(ethyl orthoacetyl)-β-L-fucopyranoside

There total 7 articles about 2-(trimethylsilyl)ethyl 2-O-benzyl-3,4-O-(ethyl orthoacetyl)-β-L-fucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16741-27-8
2,3,4-tri-O-acetyl-α-L-fucopyranosyl bromide

: 124488-73-9
2-(trimethylsilyl)ethyl 2-O-benzyl-3,4-O-(ethyl orthoacetyl)-β-L-fucopyranoside

Guidance literature:: Multi-step reaction with 6 steps

1: Ag₂CO₃, AgClO₄, molecular sieves 4 Angstroem / CH₂Cl₂ / 20 h / Ambient temperature

2: sodium methoxide / methanol / Ambient temperature

3: 95 percent / 4-toluenesulfonic acid, Drierite / dimethylformamide / 1 h / Ambient temperature

4: 93.5 percent / NaH / dimethylformamide / 5 h / 20 °C

5: 80 percent acetic acid / 4 h / 45 °C

6: 4-toluenesulfonic acid / toluene / 2 h / Ambient temperature

With calcium sulfate; 4 A molecular sieve; sodium methylate; silver perchlorate; sodium hydride; toluene-4-sulfonic acid; acetic acid; silver carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0008-6215(89)84146-1

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 124488-73-9
2-(trimethylsilyl)ethyl 2-O-benzyl-3,4-O-(ethyl orthoacetyl)-β-L-fucopyranoside

Guidance literature:: Multi-step reaction with 6 steps

1: Ag₂CO₃, AgClO₄, molecular sieves 4 Angstroem / CH₂Cl₂ / 20 h / Ambient temperature

2: sodium methoxide / methanol / Ambient temperature

3: 95 percent / 4-toluenesulfonic acid, Drierite / dimethylformamide / 1 h / Ambient temperature

4: 93.5 percent / NaH / dimethylformamide / 5 h / 20 °C

5: 80 percent acetic acid / 4 h / 45 °C

6: 4-toluenesulfonic acid / toluene / 2 h / Ambient temperature

With calcium sulfate; 4 A molecular sieve; sodium methylate; silver perchlorate; sodium hydride; toluene-4-sulfonic acid; acetic acid; silver carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0008-6215(89)84146-1

Reference yield:

: 124488-69-3
2-(Trimethylsilyl)ethyl β-L-fucopyranoside

: 124488-73-9
2-(trimethylsilyl)ethyl 2-O-benzyl-3,4-O-(ethyl orthoacetyl)-β-L-fucopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / 4-toluenesulfonic acid, Drierite / dimethylformamide / 1 h / Ambient temperature

2: 93.5 percent / NaH / dimethylformamide / 5 h / 20 °C

3: 80 percent acetic acid / 4 h / 45 °C

4: 4-toluenesulfonic acid / toluene / 2 h / Ambient temperature

With calcium sulfate; sodium hydride; toluene-4-sulfonic acid; acetic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/0008-6215(89)84146-1