Technology Process of 3-Azido-4,6-O-(R-benzylidene)-N-benzyloxycarbonyl-1,3,5-trideoxy-1,5-imino-D-altritol
There total 5 articles about 3-Azido-4,6-O-(R-benzylidene)-N-benzyloxycarbonyl-1,3,5-trideoxy-1,5-imino-D-altritol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium azide; ammonium chloride;
In
2-methoxy-ethanol;
for 36h;
Heating;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 54 percent / p-toluenesulfonic acid / dimethylformamide / 4 h / 60 - 65 °C
2: 1.) di-n-butyltin oxide, 2.) triethylamine / 1.) MeOH, reflux, 2 h, 2.) CH2Cl2, 0 deg C, 30 min; 20 deg C, 3 h
3: 75 percent / NaH / tetrahydrofuran / 18 h / 25 °C
4: 40 percent / NaN3, NH4Cl / 2-methoxy-ethanol / 36 h / Heating
With
sodium azide; sodium hydride; di(n-butyl)tin oxide; ammonium chloride; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; 2-methoxy-ethanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 54 percent / aq. NaHCO3 / 18 h / Ambient temperature
2: 54 percent / p-toluenesulfonic acid / dimethylformamide / 4 h / 60 - 65 °C
3: 1.) di-n-butyltin oxide, 2.) triethylamine / 1.) MeOH, reflux, 2 h, 2.) CH2Cl2, 0 deg C, 30 min; 20 deg C, 3 h
4: 75 percent / NaH / tetrahydrofuran / 18 h / 25 °C
5: 40 percent / NaN3, NH4Cl / 2-methoxy-ethanol / 36 h / Heating
With
sodium azide; sodium hydride; di(n-butyl)tin oxide; sodium hydrogencarbonate; ammonium chloride; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; 2-methoxy-ethanol; N,N-dimethyl-formamide;
