C₁₉H₃₃N₃O₃

Base Information

• Chemical Name: C₁₉H₃₃N₃O₃
• CAS No.: 1280013-76-4
• Molecular Formula: C₁₉H₃₃N₃O₃
• Molecular Weight: 351.489
• Mol file: 1280013-76-4.mol

Synonyms:

Chemical Property of C₁₉H₃₃N₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₃₃N₃O₃

There total 15 articles about C₁₉H₃₃N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H39N3O3 (1280013-69-5) → C19H33N3O3 (1280013-76-4)

Guidance literature:

C₂₆H₃₉N₃O₃; With 20 % Pd(OH)2/C; hydrogen; In ethanol; at 50 ℃;

With hydrogenchloride; In ethyl acetate;

DOI:10.1016/j.bmcl.2010.12.109

Reference yield:

(2S,3R)-2-(t-butoxycarbonylamino)-3-cyclohexyl-3-hydroxypropanoic acid (82655-29-6) → C19H33N3O3 (1280013-76-4)

Guidance literature:

Multi-step reaction with 4 steps

1: methanol / 55 °C

2: hydrogenchloride / water / 55 °C

3: acetic acid / toluene / 80 °C

4: 20 % Pd(OH)2/C; hydrogen / ethanol / 50 °C

With hydrogenchloride; 20 % Pd(OH)2/C; hydrogen; acetic acid; In methanol; ethanol; water; toluene; 1: Ugi condensation;

DOI:10.1016/j.bmcl.2010.12.109

Reference yield:

(4S,5R)-3-benzyl-5-cyclohexyl-4-(hydroxymethyl)oxazolidin-2-one (1280013-85-5) → C19H33N3O3 (1280013-76-4)

Guidance literature:

Multi-step reaction with 10 steps

1: Jones reagent / acetone

2: diethyl ether

3: potassium hydroxide / ethanol

4: potassium hydroxide

5: 20 % Pd(OH)2/C; hydrogen

7: methanol / 55 °C

8: hydrogenchloride / water / 55 °C

9: acetic acid / toluene / 80 °C

10: 20 % Pd(OH)2/C; hydrogen / ethanol / 50 °C

With hydrogenchloride; Jones reagent; 20 % Pd(OH)2/C; hydrogen; acetic acid; potassium hydroxide; In methanol; diethyl ether; ethanol; water; acetone; toluene; 7: Ugi condensation;

DOI:10.1016/j.bmcl.2010.12.109

upstream raw materials:

(2S,3R)-2-(t-butoxycarbonylamino)-3-cyclohexyl-3-hydroxypropanoic acid

C₂₆H₃₉N₃O₃

(4S,5R)-3-benzyl-5-cyclohexyl-4-(hydroxymethyl)oxazolidin-2-one

(4R,5R)-3-benzyl-5-cyclohexyl-2-oxo-oxazolidine-4-carboxylic acid

Downstream raw materials:

4-[4-(((3S)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl)methyl)phenoxy]benzoic acid hydrochloride

C₃₃H₄₃N₃O₆