DG172 (dihydrochloride)

Base Information

• Chemical Name: DG172 (dihydrochloride)
• CAS No.: 1361504-77-9
• Molecular Formula: C₂₀H₂₀BrN₃*2ClH
• Molecular Weight: 455.225
• Mol file: 1361504-77-9.mol

Synonyms:

Chemical Property of DG172 (dihydrochloride)

Chemical Property:

• Solubility.: ≤20mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide

Purity/Quality:

97% ^*data from raw suppliers

DG172Dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: DG-172 is an orally available inverse agonist of PPARβ/δ (IC50 = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC50 = 9.5 nM). It alters the differentiation of bone marrow cells, augmenting GM-CSF-induced development into subsets of mature and immature dendritic cells. Inverse agonists of PPARβ/δ, including DG-172, inhibit cancer cell invasion through suppression of ANGPTL4 expression.
• Uses: DG 172 Dihydrochloride is a potent peroxisome proliferator-activated receptor agonist and inhibit Angptl4 gene expression in mouse myoblasts.

Technology Process of DG172 (dihydrochloride)

There total 2 articles about DG172 (dihydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-(2-bromophenyl)acetonitrile (19472-74-3) + 4-(4-methylpiperazin-1-yl) benzaldehyde (27913-99-1) → DG172 (1361504-77-9)

Guidance literature:

2-(2-bromophenyl)acetonitrile; 4-(4-methylpiperazin-1-yl) benzaldehyde; With pyrrolidine; In methanol; at 60 ℃; for 48h;

With hydrogenchloride; In water;

DOI:10.1021/jm2017122

Reference yield:

1-methyl-piperazine (109-01-3) → DG172 (1361504-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 100 °C

2: pyrrolidine / methanol / 48 h / 60 °C

With pyrrolidine; potassium carbonate; In methanol; dimethyl sulfoxide; 2: Knoevenagel condensation;

DOI:10.1021/jm2017122

upstream raw materials:

1-methyl-piperazine

2-(2-bromophenyl)acetonitrile

4-(4-methylpiperazin-1-yl) benzaldehyde

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