2-[1-(Hydroxyimino)ethyl]phenol

Base Information

• Chemical Name: 2-[1-(Hydroxyimino)ethyl]phenol
• CAS No.: 1196-29-8
• Molecular Formula: C8H9 N O2
• Molecular Weight: 151.165
• Hs Code.: 2928000090
• European Community (EC) Number: 214-810-9
• DSSTox Substance ID: DTXSID801299050
• Mol file: 1196-29-8.mol

Synonyms:1196-29-8;1-(2-hydroxyphenyl)-1-ethanone oxime;2-(N-hydroxy-C-methylcarbonimidoyl)phenol;2'-Hydroxyacetophenone oxime;1-(2-Hydroxyphenyl)ethan-1-one oxime;54582-22-8;2-[1-(hydroxyimino)ethyl]phenol;(E)-1-(2-hydroxyphenyl)ethanone oxime;2-[(E)-N-hydroxy-C-methylcarbonimidoyl]phenol;o-hydroxyacetophenonoxim;Bionet2_000856;DTXSID801299050;(6E)-6-[1-(hydroxyamino)ethylidene]cyclohexa-2,4-dien-1-one;1-(2-Hydroxy-phenyl)-ethanone oxime;AKOS017263903;FT-0633461

Chemical Property of 2-[1-(Hydroxyimino)ethyl]phenol

Chemical Property:

• Vapor Pressure: 0.000141mmHg at 25°C
• Melting Point: 113-115°C
• Boiling Point: 297.1°Cat760mmHg
• PKA: 9.22±0.35(Predicted)
• Flash Point: 133.5°C
• PSA: 52.82000
• Density: 1.246g/cm³
• LogP: 1.59040
• Solubility.: Acetone, Chloroform, Dichloromethane, Ethyl Acetate
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 151.063328530
• Heavy Atom Count: 11
• Complexity: 156

Purity/Quality:

97% ^*data from raw suppliers

2’-HydroxyacetophenoneOxime ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=NO)C1=CC=CC=C1O
• Uses: 2’-Hydroxyacetophenone Oxime (cas# 1196-29-8) is a compound useful in organic synthesis.

Technology Process of 2-[1-(Hydroxyimino)ethyl]phenol

There total 10 articles about 2-[1-(Hydroxyimino)ethyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

o-hydroxyacetophenone (118-93-4,104809-67-8) → 2-hydroxyacetophenoneoxime (1196-29-8)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; for 0.05h; Irradiation;

Reference yield: 75.0%

3-methyl-1,2-benzisoxazole N-oxide (75632-99-4) → 2-hydroxyacetophenoneoxime (1196-29-8)

Guidance literature:

With hydrogenchloride; zinc; In ethanol; water; for 40h; Heating;

Reference yield: 70.0%

o-hydroxyacetophenone (118-93-4,104809-67-8) → 2-methyl-1,3-benzoxazole (95-21-6) + 2-hydroxyacetophenoneoxime (1196-29-8)

Guidance literature:

With acetylhydroxamic acid; sulfuric acid; In acetonitrile; at 80 ℃; for 0.133333h; under 1292.9 Torr; Microwave irradiation;

DOI:10.1016/j.tetlet.2011.09.019

upstream raw materials:

o-hydroxyacetophenone

2a,7b-Dihydro-2a,7b-dimethyl-1,2-dioxeto<3,4-b>benzofuran

3-methyl-1,2-benzisoxazole N-oxide

Phenyl acetate

Downstream raw materials:

1-(2-hydroxyphenyl)ethylamine

2-methyl-1,3-benzoxazole

3-methylbenzo[d]isoxazole

o-hydroxyacetophenone