4b,5,6,10b,11,12-hexahydrochrysene-2,8-diol

Base Information

• Chemical Name: 4b,5,6,10b,11,12-hexahydrochrysene-2,8-diol
• CAS No.: 58024-06-9
• Molecular Formula: C₁₈H₁₈O₂
• Molecular Weight: 266.34
• Mol file: 58024-06-9.mol

Synonyms:

Chemical Property of 4b,5,6,10b,11,12-hexahydrochrysene-2,8-diol

Chemical Property:

• Vapor Pressure: 6.13E-10mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4b,5,6,10b,11,12-hexahydrochrysene-2,8-diol

There total 6 articles about 4b,5,6,10b,11,12-hexahydrochrysene-2,8-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(+/-)-2,8-dimethoxy-(4bc,10bc)-4b,5,6,10b,11,12-hexahydro-chrysene (54173-10-3) → (+/-)-cis-4b.5.6.10b.11.12-hexahydro-chrysenediol-(2.8) (58024-06-9,66514-27-0,71563-78-5)

Guidance literature:

With boron tribromide;

DOI:10.1016/S0960-894X(01)00189-5

Reference yield:

N'-(6-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)-4-methylbenzenesulfonohydrazide (70157-87-8) → (+/-)-cis-4b.5.6.10b.11.12-hexahydro-chrysenediol-(2.8) (58024-06-9,66514-27-0,71563-78-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: BuLi; TMEDA

1.2: Bu₃SnCl

1.3: 80 percent / Pd₂(dba)3; NMP

2.1: 45 percent / MsOH / CH₂Cl₂

3.1: 87 percent / NaBH₄

4.1: NaH; MeI / CS₂

4.2: 40 percent / Bu₃SnH; AIBN

5.1: 73 percent / BBr₃

With sodium tetrahydroborate; n-butyllithium; methanesulfonic acid; N,N,N,N,-tetramethylethylenediamine; boron tribromide; sodium hydride; methyl iodide; In carbon disulfide; dichloromethane; 1.1: Shapiro reaction / 1.3: Stille coupling;

DOI:10.1016/S0960-894X(01)00189-5

Reference yield:

1-(6-methoxy-3,4-dihydro-naphthalen-1-yl)-2-(3-methoxy-phenyl)-ethanone (352022-37-8) → (+/-)-cis-4b.5.6.10b.11.12-hexahydro-chrysenediol-(2.8) (58024-06-9,66514-27-0,71563-78-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 45 percent / MsOH / CH₂Cl₂

2.1: 87 percent / NaBH₄

3.1: NaH; MeI / CS₂

3.2: 40 percent / Bu₃SnH; AIBN

4.1: 73 percent / BBr₃

With sodium tetrahydroborate; methanesulfonic acid; boron tribromide; sodium hydride; methyl iodide; In carbon disulfide; dichloromethane;

DOI:10.1016/S0960-894X(01)00189-5

upstream raw materials:

(+/-)-2,8-dimethoxy-(4bc,10bc)-4b,5,6,10b,11,12-hexahydro-chrysene

N'-(6-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)-4-methylbenzenesulfonohydrazide

1-(6-methoxy-3,4-dihydro-naphthalen-1-yl)-2-(3-methoxy-phenyl)-ethanone

3-methoxyphenylacetic acid chloride