5-(2-chlorophenyl)-1H-pyrazole-4-carbaldehyde

Base Information

Chemical Name:5-(2-chlorophenyl)-1H-pyrazole-4-carbaldehyde
CAS No.:199682-74-1
Molecular Formula:C₁₀H₇ClN₂O
Molecular Weight:206.631
Hs Code.:
DSSTox Substance ID:DTXSID901240949
Nikkaji Number:J889.080C
Mol file:199682-74-1.mol

Synonyms:5-(2-chlorophenyl)-1H-pyrazole-4-carbaldehyde;199682-74-1;3-(2-Chlorophenyl)-1H-pyrazole-4-carbaldehyde;DTXSID901240949;BBL020445;STK893162;AKOS000365117;AKOS001476255;BB 0249018;CS-0449229;EN300-6503438;3-(2-Chlorophenyl)-1H-pyrazole-4-carboxaldehyde;5-(2-Chloro-phenyl)-1H-pyrazole-4-carbaldeh yde;Z2757550890

Suppliers and Price of 5-(2-chlorophenyl)-1H-pyrazole-4-carbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-(2-chlorophenyl)-1H-pyrazole-4-carbaldehyde
10mg
$ 45.00

Crysdot
5-(2-Chlorophenyl)-1H-pyrazole-4-carbaldehyde 95+%
1g
$ 790.00

Chemenu
5-(2-Chlorophenyl)-1H-pyrazole-4-carbaldehyde 95%
1g
$ 746.00

American Custom Chemicals Corporation
5-(2-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 95.00%
5MG
$ 497.00

Total 8 raw suppliers

Chemical Property of 5-(2-chlorophenyl)-1H-pyrazole-4-carbaldehyde

Chemical Property:

Boiling Point:424.3±35.0 °C(Predicted)
PKA:10.28±0.50(Predicted)
Density:1.378±0.06 g/cm3(Predicted)
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:206.0246905
Heavy Atom Count:14
Complexity:212

Purity/Quality:

97% ^*data from raw suppliers

5-(2-chlorophenyl)-1H-pyrazole-4-carbaldehyde ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C2=C(C=NN2)C=O)Cl

Technology Process of 5-(2-chlorophenyl)-1H-pyrazole-4-carbaldehyde

There total 4 articles about 5-(2-chlorophenyl)-1H-pyrazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2'-chloroacetophenone semicarbazone

: 199682-74-1
3-(2-Chloro-phenyl)-1H-pyrazole-4-carbaldehyde

Guidance literature:: With trichlorophosphate; In N,N-dimethyl-formamide; at 0 - 70 ℃; for 6.5h;
DOI:10.2174/1573406412666160822160156

Reference yield:

: 2142-68-9
1-(2-chlorophenyl)ethanone

: 199682-74-1
3-(2-Chloro-phenyl)-1H-pyrazole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium acetate / water; ethanol / 50 °C

1.2: 50 °C

2.1: trichlorophosphate / 0.17 h / 0 - 5 °C

2.2: 0 - 70 °C

2.3: pH 8 - 9 / Cooling

With sodium acetate; trichlorophosphate; In ethanol; water; 2.1: |Vilsmeier-Haack Formylation / 2.2: |Vilsmeier-Haack Formylation / 2.3: |Vilsmeier-Haack Formylation;
DOI:10.1002/ardp.202000165

Reference yield:

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 2'-chloroacetophenone semicarbazone

: 199682-74-1
3-(2-Chloro-phenyl)-1H-pyrazole-4-carbaldehyde

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; at 0 - 5 ℃; for 0.166667h;

2'-chloroacetophenone semicarbazone; at 0 - 70 ℃;

With water; sodium hydroxide; pH=8 - 9; Cooling;
DOI:10.1002/ardp.202000165