Technology Process of B-homo-2-ethoxy-3,17β-estradiol
There total 6 articles about B-homo-2-ethoxy-3,17β-estradiol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
B-homo-2-ethoxy-3,17β-estradiol-7-tosylhydrazone;
With
benzo[1,3,2]dioxaborole;
In
tetrahydrofuran; chloroform;
at 0 ℃;
for 10h;
With
sodium acetate;
In
tetrahydrofuran; chloroform;
for 6h;
Further stages.;
Heating;
DOI:10.1021/jm0001119
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: imidazole / dimethylformamide / 18 h / 20 °C
2.1: lithium diisopropylamide / tetrahydrofuran / 3 h / -78 °C
2.2: butyllithium / 2.5 h / 0 °C
3.1: tetrabutylammonium fluoride / tetrahydrofuran / 4 h / 20 °C
4.1: methanol / 24 h / 20 °C
5.1: catecholborane; sodium acetate / CHCl3; H2O / 3 h / Heating
With
1H-imidazole; tetrabutyl ammonium fluoride; sodium acetate; lithium diisopropyl amide; benzo[1,3,2]dioxaborole;
In
tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1124/mol.57.3.568
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hydroxide / methanol / 4 h / 20 °C
2.1: imidazole / dimethylformamide / 18 h / 20 °C
3.1: lithium diisopropylamide / tetrahydrofuran / 3 h / -78 °C
3.2: butyllithium / 2.5 h / 0 °C
4.1: tetrabutylammonium fluoride / tetrahydrofuran / 4 h / 20 °C
5.1: methanol / 24 h / 20 °C
6.1: catecholborane; sodium acetate / CHCl3; H2O / 3 h / Heating
With
1H-imidazole; potassium hydroxide; tetrabutyl ammonium fluoride; sodium acetate; lithium diisopropyl amide; benzo[1,3,2]dioxaborole;
In
tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1124/mol.57.3.568
