2,2,5-trimethylpyrrolidine

Base Information

• Chemical Name: 2,2,5-trimethylpyrrolidine
• CAS No.: 6496-48-6
• Molecular Formula: C₇H₁₅N
• Molecular Weight: 113.203
• Mol file: 6496-48-6.mol

Synonyms:

Chemical Property of 2,2,5-trimethylpyrrolidine

Chemical Property:

• Refractive Index: 1.4223
• Boiling Point: 171.98°C (rough estimate)
• Density: 0.7980

Purity/Quality:

2,2,5-Trimethylpyrrolidine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

Technology Process of 2,2,5-trimethylpyrrolidine

There total 5 articles about 2,2,5-trimethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-methyl-2-azidohexane (76613-34-8) → 2,2,5-trimethylpyrrolidine (6496-48-6)

Guidance literature:

With C₅₆H₄₅CoN₂; In benzene; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jacs.9b09015

Reference yield:

2-methylhexan-2-ol (625-23-0) → 2,2,5-trimethylpyrrolidine (6496-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / benzene / 24 h / 20 °C / Inert atmosphere

2: C₆₆H₄₉CoN₂ / benzene / 12 h / 80 °C / Inert atmosphere

With boron trifluoride diethyl etherate; C₆₆H₄₉CoN₂; In benzene;

DOI:10.1021/jacs.9b01262

Reference yield:

5-methyl-5-nitrohexan-2-one (4604-49-3) → 2,2,5-trimethylpyrrolidine (6496-48-6)

Guidance literature:

With ethanol; nickel; at 60 ℃; under 51485.6 Torr; Hydrogenation;

DOI:10.1021/jo01137a013

upstream raw materials:

5-methyl-5-nitrohexan-2-one

2-methylhexan-2-ol

2-methyl-2-azidohexane

2-amino-5-methylhexane

Refernces

• 1、 Albrecht, Martin,Keilwerth, Martin,Meyer, Karsten,Pividori, Daniel M.,Stroek, Wowa. "An Iron-Mesoionic Carbene Complex for Catalytic Intramolecular C-H Amination Utilizing Organic Azides". . p. 20157 - 20165. Retrieved 2021/12/09.
• 2、 Baek, Yunjung,Betley, Theodore A.. "Catalytic C-H Amination Mediated by Dipyrrin Cobalt Imidos". . p. 7797 - 7806. Retrieved 2019/05/22.