Technology Process of (S)-tert-butyl-1-(5-fluoropyrimidin-2-yl)ethylcarbamate
There total 7 articles about (S)-tert-butyl-1-(5-fluoropyrimidin-2-yl)ethylcarbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-N-(1-(5-fluoropyrimidin-2-yl)ethyl)acetamide; di-tert-butyl dicarbonate;
dmap;
In
tetrahydrofuran;
at 50 ℃;
for 40h;
With
lithium hydroxide; water;
In
tetrahydrofuran;
at 20 ℃;
for 9h;
- Guidance literature:
-
With
lithium hydroxide monohydrate;
In
water;
at 20 ℃;
for 9h;
DOI:10.1021/jm800343j
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrahydrofuran; 2-methyltetrahydrofuran / -40 °C
1.2: -25 °C
2.1: (S)-1-phenyl-ethylamine; potassium dihydrogenphosphate; pyridoxal 5'-phosphate; potassium carbonate; acetic acid; ω-transaminase / water; toluene / 18 h / 29 °C / pH 7.5 / Enzymatic reaction
3.1: potassium carbonate / 2-methyltetrahydrofuran; water / 18 h / 40 °C
With
potassium dihydrogenphosphate; (S)-1-phenyl-ethylamine; pyridoxal 5'-phosphate; ω-transaminase; potassium carbonate; acetic acid;
In
tetrahydrofuran; 2-methyltetrahydrofuran; water; toluene;
1.1: |Grignard Reaction;
DOI:10.1021/op400133d
