Canthin-6-one N-oxide

Base Information

• Chemical Name: Canthin-6-one N-oxide
• CAS No.: 60755-87-5
• Molecular Formula: C₁₄H₈N₂O₂
• Molecular Weight: 236.23
• Mol file: 60755-87-5.mol

Synonyms:

Chemical Property of Canthin-6-one N-oxide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Canthin-6-oneN-oxide ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Canthin-6-one N-oxide

There total 12 articles about Canthin-6-one N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

canthin-6-one (479-43-6) → canthin-6-one-3-N-oxide (60755-87-5)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/j.bmcl.2015.11.070

Reference yield:

tryptamine (61-54-1) → canthin-6-one-3-N-oxide (60755-87-5)

Guidance literature:

Multi-step reaction with 5 steps

1: dichloromethane / 18 h / 20 °C

2: Catalytic Amberlyst H-15^? / 18 h / Reflux

3: trichlorophosphate / benzene / 16 h / Reflux

4: 1,8-diazabicyclo[5.4.0]undec-7-ene; oxygen / dichloromethane / 20 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 5 - 20 °C

With oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane; benzene; 3: |Bischler-Napieralski Reaction;

DOI:10.1002/ejoc.201300770

Reference yield:

N-(2-indol-3-yl-ethyl)-succinamic acid (92256-33-2) → canthin-6-one-3-N-oxide (60755-87-5)

Guidance literature:

Multi-step reaction with 4 steps

1: Catalytic Amberlyst H-15^? / 18 h / Reflux

2: trifluoromethylsulfonic anhydride; 2-chloropyridine / dichloromethane / 6.1 h / -78 - 20 °C

3: dmap; oxygen / toluene / 24 h / 20 °C

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 5 - 20 °C

With 2-chloropyridine; dmap; trifluoromethylsulfonic anhydride; oxygen; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; toluene;

DOI:10.1002/ejoc.201300770

upstream raw materials:

canthin-6-one

tryptamine

methyl 3-(4,9-dihydro-3H-pyrido[3,4-b]indol-1-yl)propanoate

N-(2-indol-3-yl-ethyl)-succinamic acid