rac-9,10-methanediyldioxy-(16β)-galanthane

Base Information

• Chemical Name: rac-9,10-methanediyldioxy-(16β)-galanthane
• CAS No.: 10313-53-8
• Molecular Formula: C₁₆H₁₉NO₂
• Molecular Weight: 257.332
• Mol file: 10313-53-8.mol

Synonyms:

Chemical Property of rac-9,10-methanediyldioxy-(16β)-galanthane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-9,10-methanediyldioxy-(16β)-galanthane

There total 8 articles about rac-9,10-methanediyldioxy-(16β)-galanthane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

rac-9,10-methanediyldioxy-(16β)-galanthane-5,7-dione (36066-87-2,71630-01-8,71630-02-9) → rac-9,10-methanediyldioxy-(16β)-galanthane (481-57-2,6871-57-4,6871-58-5,6871-59-6,6900-95-4,10313-53-8,63814-02-8,63814-03-9,71630-03-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1039/P19720000588

Reference yield:

4c-hydroxymethyl-(4ar,11bc)-1,3,4,4a,5,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one (36066-91-8,71629-94-2,71629-99-7) → rac-9,10-methanediyldioxy-(16β)-galanthane (481-57-2,6871-57-4,6871-58-5,6871-59-6,6900-95-4,10313-53-8,63814-02-8,63814-03-9,71630-03-0)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine

2: dimethylsulfoxide

3: aq. HCl / acetic acid

4: Ac₂O

5: LiAlH₄ / tetrahydrofuran

With hydrogenchloride; lithium aluminium tetrahydride; acetic anhydride; In tetrahydrofuran; pyridine; acetic acid; dimethyl sulfoxide;

DOI:10.1039/P19720000588

Reference yield:

8c-hydroxymethyl-(4br,8ac)-4b,5,6,7,8,8a-hexahydro-fluoreno[2,3-d][1,3]dioxol-9-one (36274-94-9) → rac-9,10-methanediyldioxy-(16β)-galanthane (481-57-2,6871-57-4,6871-58-5,6871-59-6,6900-95-4,10313-53-8,63814-02-8,63814-03-9,71630-03-0)

Guidance literature:

Multi-step reaction with 7 steps

1: NaN₃

2: K₂CO₃, H₂O / ethanol

3: pyridine

4: dimethylsulfoxide

5: aq. HCl / acetic acid

6: Ac₂O

7: LiAlH₄ / tetrahydrofuran

With hydrogenchloride; lithium aluminium tetrahydride; sodium azide; water; acetic anhydride; potassium carbonate; In tetrahydrofuran; pyridine; ethanol; acetic acid; dimethyl sulfoxide;

DOI:10.1039/P19720000588

upstream raw materials:

rac-9,10-methanediyldioxy-(16β)-galanthane-5,7-dione

4c-hydroxymethyl-(4ar,11bc)-1,3,4,4a,5,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

8c-hydroxymethyl-(4br,8ac)-4b,5,6,7,8,8a-hexahydro-fluoreno[2,3-d][1,3]dioxol-9-one

(6-oxo-(4ar,11bc)-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-4c-yl)-acetonitrile