3α-acetoxy-17-hydroxy-5β-pregnan-11-one

Base Information

• Chemical Name: 3α-acetoxy-17-hydroxy-5β-pregnan-11-one
• CAS No.: 112685-36-6
• Molecular Formula: C₂₃H₃₆O₄
• Molecular Weight: 376.536
• Mol file: 112685-36-6.mol

Synonyms:

Chemical Property of 3α-acetoxy-17-hydroxy-5β-pregnan-11-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3α-acetoxy-17-hydroxy-5β-pregnan-11-one

There total 3 articles about 3α-acetoxy-17-hydroxy-5β-pregnan-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3α-acetoxy-17,20βF-epoxy-5β-pregnan-11-one (114998-03-7,115113-36-5) → 3α-acetoxy-17-hydroxy-5β-pregnan-11-one (112685-36-6)

Guidance literature:

With chromium(VI) oxide; lithium aluminium tetrahydride; acetic anhydride; beim aufeinanderfolgenden Behandeln;

DOI:10.1016/0040-4020(58)80006-X

Reference yield:

3α-acetoxy-17-hydroxy-5β-pregnane-11,20-dione (3778-47-0) → 3α-acetoxy-17-hydroxy-5β-pregnan-11-one (112685-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide; sodium borate; water / Behandeln des Reaktionsprodukts mit Methansulfonylchlorid und Pyridin, Behandeln mit Methanol und wss. Kalilauge und anschliessend Acetylieren

2: LiAlH₄; acetic acid anhydride; CrO₃ / beim aufeinanderfolgenden Behandeln

With chromium(VI) oxide; sodium borate; lithium aluminium tetrahydride; water; acetic anhydride; N,N-dimethyl-formamide;

DOI:10.1016/0040-4020(58)80006-X

Reference yield:

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + 3α-acetoxy-17,20βF-epoxy-5β-pregnan-11-one (114998-03-7,115113-36-5) → 3α-acetoxy-17-hydroxy-5β-pregnan-11-one (112685-36-6)

Guidance literature:

Behandeln mit Acetanhydrid und Pyridin und Behandeln des isolierten Reaktionsprodukts mit Chrom(VI)-oxid und Essigsaeure;

DOI:10.1016/0040-4020(58)80006-X

upstream raw materials:

3α-acetoxy-17,20β_F-epoxy-5β-pregnan-11-one

tetrahydrofuran

3α-acetoxy-17-hydroxy-5β-pregnane-11,20-dione