2(R)-methyl,5(S)-(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine

Base Information

• Chemical Name: 2(R)-methyl,5(S)-(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine
• CAS No.: 135395-54-9
• Molecular Formula: C₆H₁₃NO₃
• Molecular Weight: 147.174
• Mol file: 135395-54-9.mol

Synonyms:

Chemical Property of 2(R)-methyl,5(S)-(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2(R)-methyl,5(S)-(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine

There total 8 articles about 2(R)-methyl,5(S)-(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C35H39NO4 → 2(R)-methyl,5(S)-(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine (135395-54-9,637771-89-2,734531-46-5)

Guidance literature:

C₃₅H₃₉NO₄; With hydrogenchloride; 10 wt% Pd(OH)2 on carbon; hydrogen; In ethanol; ethyl acetate; at 20 ℃; for 18h; under 760.051 Torr;

In ethanol; ethyl acetate;

DOI:10.1016/j.carres.2019.02.004

Reference yield:

Phosphoric acid mono-((2R,3S,4R,5S)-5-azido-2,3,4-trihydroxy-tetrahydro-pyran-2-ylmethyl) ester (136616-71-2) → 2(S)-methyl,5(S)-(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine (147060-26-2,637771-89-2,734531-46-5) + 2(R)-methyl,5(S)-(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine (135395-54-9,637771-89-2,734531-46-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In water; for 24h; under 2068.6 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00022a013

Reference yield:

C13H19NO3 → 2(R)-methyl,5(S)-(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine (135395-54-9,637771-89-2,734531-46-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; at 20 ℃; for 24h; under 3000.3 Torr;

DOI:10.1055/s-2008-1072566

upstream raw materials:

C₆H₁₀NO₇P^(2-)

Phosphoric acid mono-((2R,3S,4R,5S)-5-azido-2,3,4-trihydroxy-tetrahydro-pyran-2-ylmethyl) ester

(2S,3R,4R)-2,3,5-tri-O-benzyl-4-O-formyl-pentanal