<3.2>-metacyclophane

Base Information

• Chemical Name: <3.2>-metacyclophane
• CAS No.: 86496-48-2
• Molecular Formula: C₁₇H₁₈
• Molecular Weight: 222.33
• Mol file: 86496-48-2.mol

Synonyms:

Chemical Property of <3.2>-metacyclophane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <3.2>-metacyclophane

There total 11 articles about <3.2>-metacyclophane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

[3.2]metacyclophane-2-one (210533-81-6) → <3.2>-metacyclophane (6232-58-2,86496-48-2)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In diethylene glycol; at 130 - 200 ℃; for 6h;

DOI:10.1002/1099-0690(200107)2001:13<2487::AID-EJOC2487>3.0.CO;2-F

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + <2.2>metacyclophane-1,10-dione (22176-79-0,68907-12-0) → <3.3>-metacyclophane (62155-71-9,86496-57-3) + <3.2>-metacyclophane (6232-58-2,86496-48-2)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

Reference yield:

1,3-bis(3-bromophenyl)propane (121733-14-0) → <3.2>-metacyclophane (6232-58-2,86496-48-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) ether, 0 deg C, 4 h; 2.) overnight, RT

2: 58 percent / TiCl₄, Zn(Cu), pyridine / 1,2-dimethoxy-ethane / 72 h / Heating

3: H₂ / Pd(C)

With pyridine; n-butyllithium; zinc copper; hydrogen; titanium tetrachloride; palladium on activated charcoal; In 1,2-dimethoxyethane;

upstream raw materials:

diazomethane

<2.2>metacyclophane-1,10-dione

C₂₃H₂₆S₄

C₂₃H₂₆S₄