Ergoline, 6-methyl-8-((2-propyl-1H-imidazol-1-yl)methyl)-, (8-beta)-

Base Information

Chemical Name:Ergoline, 6-methyl-8-((2-propyl-1H-imidazol-1-yl)methyl)-, (8-beta)-
CAS No.:105579-53-1
Molecular Formula:C₂₂H₂₈N₄
Molecular Weight:348.491
Hs Code.:
DSSTox Substance ID:DTXSID50909610

Synonyms:Ergoline, 6-methyl-8-((2-propyl-1H-imidazol-1-yl)methyl)-, (8-beta)-;6-Methyl-8-((2-propyl-1H-imidazol-1-yl)methyl)ergoline (8-beta)-;105579-53-1;SCHEMBL10756767;DTXSID50909610;LS-64472;6-Methyl-8-[(2-propyl-1H-imidazol-1-yl)methyl]ergoline

Suppliers and Price of Ergoline, 6-methyl-8-((2-propyl-1H-imidazol-1-yl)methyl)-, (8-beta)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Ergoline, 6-methyl-8-((2-propyl-1H-imidazol-1-yl)methyl)-, (8-beta)-

Chemical Property:

Vapor Pressure:3.65E-13mmHg at 25°C
Boiling Point:573.6°C at 760 mmHg
Flash Point:300.7°C
Density:1.27g/cm³
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:348.23139691
Heavy Atom Count:26
Complexity:497

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC1=NC=CN1CC2CC3C(CC4=CNC5=CC=CC3=C45)N(C2)C
Isomeric SMILES:CCCC1=NC=CN1C[C@@H]2CC3[C@@H](CC4=CNC5=CC=CC3=C45)N(C2)C

Technology Process of Ergoline, 6-methyl-8-((2-propyl-1H-imidazol-1-yl)methyl)-, (8-beta)-

There total 4 articles about Ergoline, 6-methyl-8-((2-propyl-1H-imidazol-1-yl)methyl)-, (8-beta)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50995-95-4
2-propylimidazole

: 58752-31-1
6-methyl-8β-tosyloxymethyl-ergoline

: 105579-53-1,115193-13-0
1-(6-Methylergolin-8β-ylmethyl)-2-propylimidazole

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 2.) DMF, 90 deg C, 2 h;
DOI:10.1248/cpb.42.1463

Reference yield:

: 5878-43-3
9,10-dihydrolysergic acid

: 105579-53-1,115193-13-0
1-(6-Methylergolin-8β-ylmethyl)-2-propylimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: H₂SO₄

2: 82 percent / aq. NaBH₄ / methanol / 2 h / Heating

3: 80 percent / pyridine / 3 h / Ambient temperature

4: 1.) NaH / 1.) DMF, 2.) DMF, 90 deg C, 2 h

With pyridine; sodium tetrahydroborate; sulfuric acid; sodium hydride; In methanol;
DOI:10.1248/cpb.42.1463

Reference yield:

: 3006-19-7,5143-94-2,35470-53-2,77842-02-5,87247-99-2,96648-31-6,96648-32-7
9,10-dihydrolysergic acid methyl ester

: 105579-53-1,115193-13-0
1-(6-Methylergolin-8β-ylmethyl)-2-propylimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / aq. NaBH₄ / methanol / 2 h / Heating

2: 80 percent / pyridine / 3 h / Ambient temperature

3: 1.) NaH / 1.) DMF, 2.) DMF, 90 deg C, 2 h

With pyridine; sodium tetrahydroborate; sodium hydride; In methanol;
DOI:10.1248/cpb.42.1463