oxa<2.2>metacyclophane

Base Information

• Chemical Name: oxa<2.2>metacyclophane
• CAS No.: 106484-47-3
• Molecular Formula: C₁₅H₁₄O
• Molecular Weight: 210.276
• Mol file: 106484-47-3.mol

Synonyms:

Chemical Property of oxa<2.2>metacyclophane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of oxa<2.2>metacyclophane

There total 5 articles about oxa<2.2>metacyclophane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

10-oxa-2-thia<3.2>metacyclophane (117144-70-4,115018-63-8) → oxa<2.2>metacyclophane (106484-47-3,115074-94-7,117180-52-6)

Guidance literature:

With phosphorous acid trimethyl ester; for 19h; Irradiation;

Reference yield: 1.0%

C15H14Br2O → oxa<2.2>metacyclophane (106484-47-3,115074-94-7,117180-52-6)

Guidance literature:

With phenyllithium;

DOI:10.1039/C39860001248

Reference yield:

3-Hydroxybenzyl alcohol (620-24-6) → oxa<2.2>metacyclophane (106484-47-3,115074-94-7,117180-52-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / PBr₃ / CHCl₃ / 2 h / Ambient temperature

2: 1.) thiourea; 2.) NaOH / 1.) ethanol, 10 h, reflux; 2.) ethanol, H₂O, 8 h, reflux

3: 1.) KOC(CH₃)3; 2.) Cs₂CO₃ / 1.) 85percent ethanol; 2.) ethanol, 85percent ethanol, 6 h, reflux

4: 33 percent / trimethylphosphite / 19 h / Irradiation

With sodium hydroxide; potassium tert-butylate; phosphorus tribromide; caesium carbonate; thiourea; phosphorous acid trimethyl ester; In chloroform;

upstream raw materials:

10-oxa-2-thia<3.2>metacyclophane

3-Hydroxybenzyl alcohol

m-hydroxytoluene-α-thiol

m-hydroxybenzyl bromide