uridine-5'-diphosphate-2-deoxy-2-fluorogalactose

Base Information

• Chemical Name: uridine-5'-diphosphate-2-deoxy-2-fluorogalactose
• CAS No.: 118694-15-8
• Molecular Formula: C₁₅H₂₃FN₂O₁₆P₂
• Molecular Weight: 568.297
• Mol file: 118694-15-8.mol

Synonyms:

Chemical Property of uridine-5'-diphosphate-2-deoxy-2-fluorogalactose

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of uridine-5'-diphosphate-2-deoxy-2-fluorogalactose

There total 3 articles about uridine-5'-diphosphate-2-deoxy-2-fluorogalactose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

uridine 5'-diphosphoglucose disodium salt (6858-46-4,7333-33-7,14656-80-5,28053-08-9,53829-41-7,108320-88-3,137868-52-1) + 2-deoxy-2-fluoro-α-D-galactopyranosyl phosphate (209005-34-5) → uridine-5'-diphosphate-2-deoxy-2-fluorogalactose (118694-15-8)

Guidance literature:

With galactose-1-phosphate uridyl transferase; nicotinamide adenine dinucleotide phosphate (NADP⁺); diothiothreitol; In various solvent(s); at 37 ℃; for 48h; pH=8.0;

DOI:10.1016/S0008-6215(00)00135-X

Reference yield:

2-deoxy-2-fluoro-D-galactose (238418-53-6) → uridine-5'-diphosphate-2-deoxy-2-fluorogalactose (118694-15-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Mg*adenosine 5'-triphosphate (Mg*ATP); phosphoenolpyruvate; galactokinase / various solvent(s) / 2 h / 37 °C / pH 8.0

2: galactose-1-phosphate uridyl transferase; nicotinamide adenine dinucleotide phosphate (NADP⁺); dithiothreitol (DTT) / various solvent(s) / 48 h / 37 °C / pH 8.0

With galactokinase; phosphoenolpyruvic acid; galactose-1-phosphate uridyl transferase; nicotinamide adenine dinucleotide phosphate (NADP⁺); magnesium salt of ATP; diothiothreitol; In various solvent(s); 1: phosphorylation / 2: uridylation;

DOI:10.1016/S0008-6215(00)00135-X

Reference yield:

uridine 5'-diphosphoglucose disodium salt (6858-46-4,7333-33-7,14656-80-5,28053-08-9,53829-41-7,108320-88-3,137868-52-1) + Phosphoric acid mono-((3R,4S,5R,6R)-3-fluoro-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl) ester → uridine-5'-diphosphate-2-deoxy-2-fluorogalactose (118694-15-8)

Guidance literature:

With potassium hydroxide; inorganic pyrophosphatase; galactose-1-phosphate uridyl transferase; uridine-5'-diphosphoglucose pyrophosphorylase; uridine 5'-triphosphate trisodium salt; magnesium chloride; manganese(ll) chloride; diothiothreitol; for 72h; Yield given; Ambient temperature;

DOI:10.1016/S0968-0896(96)00263-5

upstream raw materials:

uridine 5'-diphosphoglucose disodium salt

2-deoxy-2-fluoro-α-D-galactopyranosyl phosphate

2-deoxy-2-fluoro-D-galactose