1-octadecanoyl-2-[cis-9,12]-octadecadienoyl-glycero-3-phosphocholine

Base Information

• Chemical Name: 1-octadecanoyl-2-[cis-9,12]-octadecadienoyl-glycero-3-phosphocholine
• CAS No.: 6753-53-3
• Molecular Formula: C₄₄H₈₄NO₈P
• Molecular Weight: 786.127
• Mol file: 6753-53-3.mol

Synonyms:

Chemical Property of 1-octadecanoyl-2-[cis-9,12]-octadecadienoyl-glycero-3-phosphocholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-octadecanoyl-2-[cis-9,12]-octadecadienoyl-glycero-3-phosphocholine

There total 2 articles about 1-octadecanoyl-2-[cis-9,12]-octadecadienoyl-glycero-3-phosphocholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{2-[(2,3-bis-stearoyloxy-propoxy)-hydroxy-phosphoryloxy]-ethyl}-trimethyl-ammonium betaine (816-94-4,4539-70-2,66701-63-1,816-93-3,18603-43-5) → 1-octadecanoyl-2-[cis-9,12]-octadecadienoyl-glycero-3-phosphocholine (6753-53-3,70106-57-9,923-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / 5 mM CaCl₂ / diethyl ether / 3 h / 29 °C / phospholipase A₂, 0.1 M pH 7.2 Tris buffer

2: 1.) tetraethylammonium salt of linoleic acid / 1.) chloroform, reduced pressure, evaporation, 2.) chloroform, 60 deg C, 70 h, reduced pressure

With tetraethylammonium salt of linoleic acid; calcium chloride; In diethyl ether;

DOI:10.1002/mrc.1270180211

Reference yield:

linoleic acid anhydride (24909-68-0) + 1-stearoyl-sn-glycero-3-phosphocholine (17364-19-1,5655-17-4) → 1-octadecanoyl-2-[cis-9,12]-octadecadienoyl-glycero-3-phosphocholine (6753-53-3,70106-57-9,923-59-1)

Guidance literature:

With tetraethylammonium salt of linoleic acid; Yield given. Multistep reaction; 1.) chloroform, reduced pressure, evaporation, 2.) chloroform, 60 deg C, 70 h, reduced pressure;

DOI:10.1002/mrc.1270180211

upstream raw materials:

linoleic acid anhydride

1-stearoyl-sn-glycero-3-phosphocholine

{2-[(2,3-bis-stearoyloxy-propoxy)-hydroxy-phosphoryloxy]-ethyl}-trimethyl-ammonium betaine