3-FORMYLPHENYL THIOPHENE-2-CARBOXYLATE

Base Information

• Chemical Name: 3-FORMYLPHENYL THIOPHENE-2-CARBOXYLATE
• CAS No.: 361367-12-6
• Molecular Formula: C₁₂H₈O₃S
• Molecular Weight: 232.26
• Mol file: 361367-12-6.mol

Synonyms:

Chemical Property of 3-FORMYLPHENYL THIOPHENE-2-CARBOXYLATE

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

3-Formylphenyl thiophene-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 3-FORMYLPHENYL THIOPHENE-2-CARBOXYLATE

There total 2 articles about 3-FORMYLPHENYL THIOPHENE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

copper(I) thiophene-2-carboxylate (1292766-17-6) + m-formylphenyl benzoic acid (619-21-6) → 3-formylphenyl thiophene-2-formate (361367-12-6)

Guidance literature:

m-formylphenyl benzoic acid; With lithium hydroxide; In water; acetonitrile; at 25 ℃; for 1h;

copper(I) thiophene-2-carboxylate; With copper(II) bis(trifluoromethanesulfonate); In acetonitrile; at 35 ℃; for 15h; Irradiation; Inert atmosphere; Glovebox;

DOI:10.1002/anie.202108971

Reference yield:

→ 3-formylphenyl thiophene-2-formate (361367-12-6)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 - 30 ℃;

Reference yield:

3-formylphenyl thiophene-2-formate (361367-12-6) → meta-hydroxybenzaldehyde (100-83-4)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; at 40 ℃;

DOI:10.1002/anie.202108971

upstream raw materials:

copper(I) thiophene-2-carboxylate

m-formylphenyl benzoic acid

Downstream raw materials:

meta-hydroxybenzaldehyde

Refernces

• 1、 -. "Thiazole amide compound and preparation method, pharmaceutical composition and application thereof". Paragraph 0207; 0231; 0308; 0309; 0310. . Retrieved 2019/01/08.