4-Piperidinemethanamine, 1-(3-chloro-4-fluorobenzoyl)-4-fluoro-N-((5-methyl-2-pyrimidinyl)methyl)-

Base Information

Chemical Name:4-Piperidinemethanamine, 1-(3-chloro-4-fluorobenzoyl)-4-fluoro-N-((5-methyl-2-pyrimidinyl)methyl)-
CAS No.:635323-95-4
Molecular Formula:C₁₉H₂₁ClF₂N₄O
Molecular Weight:394.852
Hs Code.:
UNII:83481Y1YCX
ChEMBL ID:CHEMBL230963
DSSTox Substance ID:DTXSID901029377
Nikkaji Number:J2.866.554G
Pharos Ligand ID:VFMXZT1ZUKY4
Wikidata:Q5423588
Wikipedia:F-15,599

Synonyms:3-chloro-4-fluorophenyl-(4-fluoro-4-(((5-methylpyrimidin-2-ylmethyl)amino)methyl)piperidin-1-yl)methanone;F 15599;F-15599;F15599;NLX-101

Suppliers and Price of 4-Piperidinemethanamine, 1-(3-chloro-4-fluorobenzoyl)-4-fluoro-N-((5-methyl-2-pyrimidinyl)methyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
NLX-101（F-15599）
250 mg
$ 850.00

DC Chemicals
NLX-101（F-15599）
100 mg
$ 500.00

ChemScene
F-15599 99.61%
20mg
$ 7308.00

ChemScene
F-15599 99.61%
10mg
$ 4140.00

ChemScene
F-15599 99.61%
5mg
$ 2436.00

ChemScene
F-15599 99.61%
1mg
$ 1224.00

Total 9 raw suppliers

Chemical Property of 4-Piperidinemethanamine, 1-(3-chloro-4-fluorobenzoyl)-4-fluoro-N-((5-methyl-2-pyrimidinyl)methyl)-

Chemical Property:

Melting Point:195 °C
Boiling Point:534.7±50.0 °C(Predicted)
Density:1.33±0.1 g/cm3(Predicted)
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:394.1371953
Heavy Atom Count:27
Complexity:496

Purity/Quality:

97% ^*data from raw suppliers

NLX-101（F-15599） ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CN=C(N=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F

Technology Process of 4-Piperidinemethanamine, 1-(3-chloro-4-fluorobenzoyl)-4-fluoro-N-((5-methyl-2-pyrimidinyl)methyl)-

There total 8 articles about 4-Piperidinemethanamine, 1-(3-chloro-4-fluorobenzoyl)-4-fluoro-N-((5-methyl-2-pyrimidinyl)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 448920-98-7
2-[1-[(3-chloro-4-fluorophenyl)carbonyl]-4-fluoropiperidin-4-yl]-2-hydroxyacetonitrile

: 1346542-72-0,930272-59-6
5-methylpyrimidine-2-methylamine dihydrochloride

: 635323-95-4
F₁₅₅₉₉

Guidance literature:: 2-[1-[(3-chloro-4-fluorophenyl)carbonyl]-4-fluoropiperidin-4-yl]-2-hydroxyacetonitrile; 5-methylpyrimidine-2-methylamine dihydrochloride; With 1,4-diaza-bicyclo[2.2.2]octane; sodium cyanoborohydride; In methanol; at 50 ℃; for 6h; Molecular sieve;

With hydrogenchloride; In dichloromethane; water;

With ammonia; In water;

Reference yield: 71.0%

: 448920-98-7
2-[1-[(3-chloro-4-fluorophenyl)carbonyl]-4-fluoropiperidin-4-yl]-2-hydroxyacetonitrile

: 930272-60-9
(5-methylpyrimidin-2-yl)methanamine

: 635323-95-4
F₁₅₅₉₉

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; 4 A molecular sieve; sodium cyanoborohydride; In methanol; at 50 ℃; for 6h;
DOI:10.1021/jm070714l