4-(3,4-DIMETHOXY-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER

Base Information

• Chemical Name: 4-(3,4-DIMETHOXY-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER
• CAS No.: 70311-75-0
• Molecular Formula: C₁₃H₁₄O₆
• Molecular Weight: 266.251
• Mol file: 70311-75-0.mol

Synonyms:

Chemical Property of 4-(3,4-DIMETHOXY-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

METHYL 4-(3,4-DIMETHOXYPHENYL)-2,4-DIOXOBUTANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3,4-DIMETHOXY-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER

There total 1 articles about 4-(3,4-DIMETHOXY-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Dimethyl oxalate (553-90-2) + 1-(3,4-dimethoxyphenyl)ethanone (1131-62-0) → methyl 4-(3,4-dimethoxyphenyl)-2,4-dioxobutanoate (70311-75-0)

Guidance literature:

With sodium methylate; Inert atmosphere;

DOI:10.1016/j.bmcl.2016.02.072

Reference yield:

methyl 4-(3,4-dimethoxyphenyl)-2,4-dioxobutanoate (70311-75-0) → C13H13NO5 (517870-17-6)

Guidance literature:

With hydroxylamine hydrochloride; In methanol; for 3h; Reflux;

DOI:10.1016/j.bmcl.2012.10.099

Reference yield:

methyl 4-(3,4-dimethoxyphenyl)-2,4-dioxobutanoate (70311-75-0) → (7-(3,4-dimethoxyphenyl)-2-phenylpyrazolo[1,5-a]pyrimidin-5-yl)(4-(2-(2,4-dimethoxyphenylamino)nicotinoyl)piperazin-1-yl)methanone

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol

2: sodium hydroxide / methanol / 2 h / Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; ethanol;

DOI:10.1016/j.bmcl.2016.02.072

upstream raw materials:

Dimethyl oxalate

1-(3,4-dimethoxyphenyl)ethanone

Downstream raw materials:

C₁₃H₁₃NO₅