4-methoxyphenyl 2-(4-isobutylphenyl)propanoate

Base Information

• Chemical Name: 4-methoxyphenyl 2-(4-isobutylphenyl)propanoate
• CAS No.: 666214-15-9
• Molecular Formula: C₂₀H₂₄O₃
• Molecular Weight: 312.409
• Mol file: 666214-15-9.mol

Synonyms:

Chemical Property of 4-methoxyphenyl 2-(4-isobutylphenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methoxyphenyl 2-(4-isobutylphenyl)propanoate

There total 4 articles about 4-methoxyphenyl 2-(4-isobutylphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-isobutylphenyl(mesityl)iodonium trifluoromethanesulfonate (1330681-32-7) → 4-methoxyphenyl 2-(4-isobutylphenyl)propanoate (666214-15-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / tert-butyl alcohol / 70 °C / Inert atmosphere

2: caesium carbonate; tetrabutylammomium bromide / 24 h / 20 °C / Inert atmosphere

With potassium tert-butylate; tetrabutylammomium bromide; caesium carbonate; In tert-butyl alcohol;

DOI:10.1002/ejoc.201800331

Reference yield:

5-(4-isobutylphenyl)-2,2,5-trimethyl-1,3-dioxane-4,6-dione (92978-26-2) + 4-methoxy-phenol (150-76-5) → 4-methoxyphenyl 2-(4-isobutylphenyl)propanoate (666214-15-9)

Guidance literature:

With tetrabutylammomium bromide; caesium carbonate; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201800331

Reference yield:

5-(4-isobutylphenyl)-2,2,5-trimethyl-1,3-dioxane-4,6-dione (92978-26-2) + 4-methoxy-phenol (150-76-5) → (S)-4-methoxyphenyl 2-(4-isobutylphenyl)propanoate (666214-15-9) + (R)-4-methoxyphenyl 2-(4-isobutylphenyl)propanoate (666214-15-9)

Guidance literature:

With potassium phosphate; (R)-2,10-di-tert-butyl-3,9-dimethoxy-6-methyl-6-(1-naphthalen-1-ylethyl)-4,8-bis(3,4,5-trifluorophenyl)-6,7-dihydro-5H-dibenzo[c,e]-azepinium bromide; cesium chloride; at 20 ℃; for 48h; Overall yield = 64 %; Overall yield = 40.1 mg; enantioselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201800331

upstream raw materials:

5-(4-isobutylphenyl)-2,2,5-trimethyl-1,3-dioxane-4,6-dione

4-methoxy-phenol

4-isobutylphenyl(mesityl)iodonium trifluoromethanesulfonate