Motesanib metabolite M3

Base Information

Chemical Name:Motesanib metabolite M3
CAS No.:1026278-72-7
Molecular Formula:C₂₂H₂₃N₅O₂
Molecular Weight:389.457
Hs Code.:
UNII:54WC7W3QYB

Synonyms:Motesanib metabolite M3;54WC7W3QYB;UNII-54WC7W3QYB;1026278-72-7;3-Pyridinecarboxamide, N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-(((1-oxido-4-pyridinyl)methyl)amino)-;SCHEMBL4537062

Suppliers and Price of Motesanib metabolite M3

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of Motesanib metabolite M3

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:389.18517499
Heavy Atom Count:29
Complexity:563

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=[N+](C=C4)[O-])C

Technology Process of Motesanib metabolite M3

There total 2 articles about Motesanib metabolite M3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1376615-68-7
4-(((3-((1-acetyl-3,3-dimethylindolin-6-yl)carbamoyl)pyridin-2-yl)amino)methyl)pyridine 1-oxide

: 1026278-72-7
4-(((3-((3,3-dimethylindolin-6-yl)carbamoyl)pyridin-2-yl)amino)methyl)pyridine 1-oxide

Guidance literature:: 4-(((3-((1-acetyl-3,3-dimethylindolin-6-yl)carbamoyl)pyridin-2-yl)amino)methyl)pyridine 1-oxide; With hydrogenchloride; water; In ethanol; at 70 ℃;

With sodium hydroxide; In water; pH=7 - 8;

Reference yield:

: 453562-74-8
N-(1-acetyl-3,3-dimethylindolin-6-yl){2-[(4-pyridylmethyl)-amino](3-pyridyl)}-carboxamide

: 1026278-72-7
4-(((3-((3,3-dimethylindolin-6-yl)carbamoyl)pyridin-2-yl)amino)methyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 20 °C

2.1: hydrogenchloride; water / ethanol / 70 °C

2.2: pH 7 - 8

With hydrogenchloride; water; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;