10t-oxy-(6at)-4,5,6,6a,7,8,9,11-octahydro-4r,9c-cyclo-pyrrolo[1,2-a]thieno[2,3-f]azepine-5t-carboxylic acid methyl ester

Base Information

• Chemical Name: 10t-oxy-(6at)-4,5,6,6a,7,8,9,11-octahydro-4r,9c-cyclo-pyrrolo[1,2-a]thieno[2,3-f]azepine-5t-carboxylic acid methyl ester
• CAS No.: 73136-78-4
• Molecular Formula: C₁₄H₁₇NO₃S
• Molecular Weight: 279.36
• Mol file: 73136-78-4.mol

Synonyms:

Chemical Property of 10t-oxy-(6at)-4,5,6,6a,7,8,9,11-octahydro-4r,9c-cyclo-pyrrolo[1,2-a]thieno[2,3-f]azepine-5t-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10t-oxy-(6at)-4,5,6,6a,7,8,9,11-octahydro-4r,9c-cyclo-pyrrolo[1,2-a]thieno[2,3-f]azepine-5t-carboxylic acid methyl ester

There total 2 articles about 10t-oxy-(6at)-4,5,6,6a,7,8,9,11-octahydro-4r,9c-cyclo-pyrrolo[1,2-a]thieno[2,3-f]azepine-5t-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6at)-4,5,6,6a,7,8,9,11-octahydro-4r,9c-cyclo-pyrrolo[1,2-a]thieno[2,3-f]azepine-5t-carboxylic acid methyl ester (67597-76-6,73136-76-2) → 10t-oxy-(6at)-4,5,6,6a,7,8,9,11-octahydro-4r,9c-cyclo-pyrrolo[1,2-a]thieno[2,3-f]azepine-5t-carboxylic acid methyl ester (67597-78-8,73136-78-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In diethyl ether;

DOI:10.1021/jo00418a009

Reference yield:

8-methyl-2exo-thiophen-2-yl-nortropane-3exo-carboxylic acid methyl ester (67597-72-2,68366-43-8,68366-44-9,73098-97-2,73098-98-3) → 10t-oxy-(6at)-4,5,6,6a,7,8,9,11-octahydro-4r,9c-cyclo-pyrrolo[1,2-a]thieno[2,3-f]azepine-5t-carboxylic acid methyl ester (67597-78-8,73136-78-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) diethyl azodicarboxylate, benzene, (ii) HCl, MeOH

2: MCPBA / diethyl ether

With 3-chloro-benzenecarboperoxoic acid; In diethyl ether;

DOI:10.1021/jo00418a009

upstream raw materials:

(6at)-4,5,6,6a,7,8,9,11-octahydro-4r,9c-cyclo-pyrrolo[1,2-a]thieno[2,3-f]azepine-5t-carboxylic acid methyl ester

8-methyl-2exo-thiophen-2-yl-nortropane-3exo-carboxylic acid methyl ester