L-Arginine-7-amido-4-methylcoumarin hydrochloride

Base Information

Chemical Name:L-Arginine-7-amido-4-methylcoumarin hydrochloride
CAS No.:69304-16-1
Molecular Formula:C₁₆H₂₁N₅O₃*2ClH
Molecular Weight:404.296
Hs Code.:
DSSTox Substance ID:DTXSID50585054

Synonyms:69304-16-1;L-Arginine-7-amido-4-methylcoumarin hydrochloride;L-ARGININE 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE;(2S)-2-amino-5-(diaminomethylideneamino)-N-(4-methyl-2-oxochromen-7-yl)pentanamide;hydrochloride;70274-89-4;(S)-2-amino-5-guanidino-N-(4-methyl-2-oxo-2H-chromen-7-yl)pentanamide hydrochloride;Arg-mca hydrochloride;H-Arg-AMC HCl;H-Arg-AMC hydrochloride;SCHEMBL380910;DTXSID50585054;MFCD00058184;L-Arginine-7-amido-4-methylcoumarin hydrochloride, cathepsin H substrate;(S)-2-Amino-5-guanidino-N-(4-methyl-2-oxo-2H-chromen-7-yl)pentanamide xhydrochloride

Suppliers and Price of L-Arginine-7-amido-4-methylcoumarin hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
L-Arginine-7-amido-4-methylcoumarin hydrochloride cathepsin H substrate
25mg
$ 391.00

Sigma-Aldrich
L-Arginine-7-amido-4-methylcoumarin hydrochloride cathepsin H substrate
5mg
$ 119.00

American Custom Chemicals Corporation
L-ARGININE-7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE 95.00%
100MG
$ 905.93

American Custom Chemicals Corporation
L-ARGININE-7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE 95.00%
25MG
$ 665.81

Total 5 raw suppliers

Chemical Property of L-Arginine-7-amido-4-methylcoumarin hydrochloride

Chemical Property:

Storage Temp.:−20°C
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:367.1411173
Heavy Atom Count:25
Complexity:542

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-Arginine-7-amido-4-methylcoumarin hydrochloride cathepsin H substrate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CCCN=C(N)N)N.Cl
Isomeric SMILES:CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CCCN=C(N)N)N.Cl
Uses L-Arginine-7-amido-4-methylcoumarin hydrochloride has been used as a?substrate for cathepsin H from rat muscle homogenate and sarcoplasmic extract. It has also been used as a?substrate for arginine amino-peptidase from Daphnia homogenates and recombinant aminopeptidase?from Toxoplasma gondii. L-Arginine 7-Amido-4-methylcoumarin Dihydrochloride is a fluorogenic peptide-based substrate used in the monitoring of thrombin activity.

Technology Process of L-Arginine-7-amido-4-methylcoumarin hydrochloride

There total 3 articles about L-Arginine-7-amido-4-methylcoumarin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: Boc-Arg-AMC*HCl

: 69304-16-1,70274-89-4
H-Arg-AMC*2HCl

Guidance literature:: With hydrogenchloride; In diethyl ether; ethyl acetate; at 20 ℃;
DOI:10.1039/b906762k

Reference yield:

: 26093-31-2
7-amino-4-methylcoumarin.

: 69304-16-1,70274-89-4
H-Arg-AMC*2HCl

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; trichlorophosphate / -15 - 20 °C

2: hydrogenchloride / diethyl ether; ethyl acetate / 20 °C

With pyridine; hydrogenchloride; trichlorophosphate; In diethyl ether; ethyl acetate;
DOI:10.1039/b906762k

Reference yield:

: 13726-76-6,78603-12-0
t-butyloxycarbonyl-L-arginine

: 69304-16-1,70274-89-4
H-Arg-AMC*2HCl

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; trichlorophosphate / -15 - 20 °C

2: hydrogenchloride / diethyl ether; ethyl acetate / 20 °C

With pyridine; hydrogenchloride; trichlorophosphate; In diethyl ether; ethyl acetate;
DOI:10.1039/b906762k