2-Propenoic Acid, 3-(2-Fluoro-4-Hydroxyphenyl)-, Ethyl Ester, (2E)

Base Information

Chemical Name:2-Propenoic Acid, 3-(2-Fluoro-4-Hydroxyphenyl)-, Ethyl Ester, (2E)
CAS No.:696589-24-9
Molecular Formula:C₁₁H₁₁FO₃
Molecular Weight:210.205
Hs Code.:
Mol file:696589-24-9.mol

Synonyms:

Suppliers and Price of 2-Propenoic Acid, 3-(2-Fluoro-4-Hydroxyphenyl)-, Ethyl Ester, (2E)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(E)-Ethyl3-(2-fluoro-4-hydroxyphenyl)acrylate 95+%
5g
$ 2679.00

Crysdot
(E)-Ethyl3-(2-fluoro-4-hydroxyphenyl)acrylate 95+%
1g
$ 892.00

Total 3 raw suppliers

Chemical Property of 2-Propenoic Acid, 3-(2-Fluoro-4-Hydroxyphenyl)-, Ethyl Ester, (2E)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(E)-Ethyl3-(2-fluoro-4-hydroxyphenyl)acrylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Propenoic Acid, 3-(2-Fluoro-4-Hydroxyphenyl)-, Ethyl Ester, (2E)

There total 1 articles about 2-Propenoic Acid, 3-(2-Fluoro-4-Hydroxyphenyl)-, Ethyl Ester, (2E) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.3%

: 121219-03-2
4-bromo-3-fluorophenol

: 140-88-5,9003-32-1
ethyl acrylate

: 696589-24-9
(Ε)-3-(2-fluoro-4-hydroxyphenyl)acrylic acid ethyl ester

Guidance literature:: With palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 100 ℃; for 72h; Inert atmosphere;

Reference yield:

: 696589-24-9
(Ε)-3-(2-fluoro-4-hydroxyphenyl)acrylic acid ethyl ester

: 3-(2-(2,’6’-dimethyl-4’-(3-(methylsulfonyl)propoxy)[1,1’-biphenyl]-3-yl)-7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 12 h

2: sulfuric acid; N-iodo-succinimide; acetic acid / 12 h / 20 - 30 °C / Inert atmosphere

3: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene / 1.5 h / 50 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / Inert atmosphere

5: palladium diacetate; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; caesium carbonate / toluene / 12 h / 80 °C / Inert atmosphere

6: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 70 °C / Inert atmosphere

With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; N-iodo-succinimide; tributylphosphine; sulfuric acid; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; palladium diacetate; caesium carbonate; acetic acid; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; toluene;

Reference yield:

: 696589-24-9
(Ε)-3-(2-fluoro-4-hydroxyphenyl)acrylic acid ethyl ester

: ethyl 3-(2-fluoro-4-hydroxy-5-iodophenyl)propionate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 12 h

2: sulfuric acid; N-iodo-succinimide; acetic acid / 12 h / 20 - 30 °C / Inert atmosphere

With N-iodo-succinimide; sulfuric acid; palladium 10% on activated carbon; hydrogen; acetic acid; In tetrahydrofuran; methanol;