[S(R)]-N-[(4S)-4-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]-2-methyl-2-propanesulfinamide

Base Information

• Chemical Name: [S(R)]-N-[(4S)-4-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]-2-methyl-2-propanesulfinamide
• CAS No.: 674767-90-9
• Molecular Formula: C₂₀H₂₁Cl₂NOS
• Molecular Weight: 394.365
• Mol file: 674767-90-9.mol

Synonyms:

Chemical Property of [S(R)]-N-[(4S)-4-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]-2-methyl-2-propanesulfinamide

Chemical Property:

• Solubility.: Dichloromethane

Purity/Quality:

97% ^*data from raw suppliers

[S(R)]-N-[(4S)-4-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]-2-methyl-2-propanesulfinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Sertraline intermediate.

Technology Process of [S(R)]-N-[(4S)-4-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]-2-methyl-2-propanesulfinamide

There total 5 articles about [S(R)]-N-[(4S)-4-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]-2-methyl-2-propanesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one (79560-19-3,79836-44-5) + (S)-2-methylpropane-2-sulfinamide (343338-28-3) → (S)-N-(4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene)-2-methylpropane-2-sulfinamide (674767-90-9)

Guidance literature:

With titanium(IV) isopropylate; In neat (no solvent); at 70 ℃; for 4h; Reagent/catalyst; Solvent;

DOI:10.1021/acs.oprd.6b00188

Reference yield:

4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one (79560-19-3,79836-44-5) + (R)-2-methylpropane-2-sulfinamide (196929-78-9) → 2-methyl-propane-2-sulfinic acid [4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalen-y-yl]-amide (674767-90-9) + 2-methyl-propane-2-sulfinic acid [4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalen-yl]-amide (674767-90-9)

Guidance literature:

With titanium (IV) ethoxide; In tetrahydrofuran; ethanol; at 60 ℃; for 13h;

Reference yield:

4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one (79560-19-3,79836-44-5) + (R)-2-methylpropane-2-sulfinamide (196929-78-9) → 2-methyl-propane-2-sulfinic acid [4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalen-y-yl]-amide (674767-90-9) + 2-methyl-propane-2-sulfinic acid [4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalen-yl]-amide (674767-90-9)

Guidance literature:

With titanium (IV) ethoxide; In tetrahydrofuran; ethanol; at 60 ℃; for 13h;

upstream raw materials:

4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one

(R)-2-methylpropane-2-sulfinamide

(4S)-4-(3,4-dichlorophenyl)-1-tetralone

(S)-2-methylpropane-2-sulfinamide