DOXYCYCLINE

Base Information

• Chemical Name: DOXYCYCLINE
• CAS No.: 7164-70-7
• Molecular Formula: C₂₂H₂₄N₂O₈
• Molecular Weight: 444.441
• Mol file: 7164-70-7.mol

Synonyms:

Chemical Property of DOXYCYCLINE

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of DOXYCYCLINE

There total 9 articles about DOXYCYCLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

methacycline hydrochloride (3963-95-9) → doxycycline (564-25-0,10597-92-9,7164-70-7,7264-10-0) + 6-epidoxycycline (3219-99-6,10597-92-9,7164-70-7,7264-10-0)

Guidance literature:

With hydrogen; closo-3,3-(η²,η³-C7H7CH2)-3,1,2-RhC2B9H11; In methanol; at 43 ℃; for 4h; under 76000 Torr;

DOI:10.1016/S0040-4039(00)60321-0

Reference yield: 41.0%

methacycline hydrochloride (3963-95-9) → doxycycline (564-25-0,10597-92-9,7164-70-7,7264-10-0) + 6-epidoxycycline (3219-99-6,10597-92-9,7164-70-7,7264-10-0)

Guidance literature:

With hydrogen; closo-3,3-(η²,η³-C7H7CH2)-3,1,2-RhC2B9H11; In methanol; at 43 ℃; for 4h; under 76000 Torr;

DOI:10.1016/S0040-4039(00)60321-0

Reference yield:

C37H34N2O10 → doxycycline (564-25-0,10597-92-9,7164-70-7,7264-10-0)

Guidance literature:

With hydrogen; palladium; In tetrahydrofuran; methanol; at 23 ℃; for 2h; under 760.051 Torr;

upstream raw materials:

doxycycline

methacycline hydrochloride

doxycycline hydrochloride

Refernces

• 1、 Legendre, Alexandre O.,Silva, Laila R. R.,Silva, Douglas M.,Rosa, Iara M. L.,Azarias, Lilian C.,De Abreu, Polyana J.,De Araujo, Magali B.,Neves, Person P.,Torres, Claudia,Martins, Felipe T.,Doriguetto, Antonio C.. "Solid state chemistry of the antibiotic doxycycline: Structure of the neutral monohydrate and insights into its poor water solubility". experimental part. p. 2532 - 2540. Retrieved 2012/07/28.
• 2、 Kertscher,Habermann,Pohle,Tauchert,Hennig,Eger. "Preparation and characterization of 4-epidoxycycline". . p. 287 - 296. Retrieved 2007/10/03.