Technology Process of <2>metacyclo<2>(2,5)thiophenophane
There total 5 articles about <2>metacyclo<2>(2,5)thiophenophane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1) thiourea, 2) 5percent aq. NaOH / 1) DMSO, 14 h, room temp., 2) 1 h
2: 44 percent / KOH, NaBH4 / ethanol; benzene / Ambient temperature
3: 100 percent / 80percent m-CPBA / CH2Cl2 / Ambient temperature
4: 67 percent / 480 °C / 0.4 - 0.8 Torr
5: 1) 1.6 M n-BuLi, 2) 10percent HCl / 1) THF, hexane, -70 deg C, 1 h, 2) 1 h
With
hydrogenchloride; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; thiourea; 3-chloro-benzenecarboperoxoic acid;
In
ethanol; dichloromethane; benzene;
DOI:10.1021/jo00008a046
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 44 percent / KOH, NaBH4 / ethanol; benzene / Ambient temperature
2: 100 percent / 80percent m-CPBA / CH2Cl2 / Ambient temperature
3: 67 percent / 480 °C / 0.4 - 0.8 Torr
4: 1) 1.6 M n-BuLi, 2) 10percent HCl / 1) THF, hexane, -70 deg C, 1 h, 2) 1 h
With
hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; n-butyllithium; 3-chloro-benzenecarboperoxoic acid;
In
ethanol; dichloromethane; benzene;
DOI:10.1021/jo00008a046
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 100 percent / 80percent m-CPBA / CH2Cl2 / Ambient temperature
2: 67 percent / 480 °C / 0.4 - 0.8 Torr
3: 1) 1.6 M n-BuLi, 2) 10percent HCl / 1) THF, hexane, -70 deg C, 1 h, 2) 1 h
With
hydrogenchloride; n-butyllithium; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
DOI:10.1021/jo00008a046
