4-[2-[4-(3-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine

Base Information

Chemical Name:4-[2-[4-(3-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine
CAS No.:597544-21-3
Molecular Formula:C₂₃H₂₃N₅O₂
Molecular Weight:401.468
Hs Code.:
Nikkaji Number:J1.829.553I
Pharos Ligand ID:YDCT7C1N32YA
ChEMBL ID:CHEMBL324153
Mol file:597544-21-3.mol

Synonyms:597544-21-3;pyrazolo[1,5-a]pyrimidine 4h;4-[2-[4-(3-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine;CHEMBL324153;Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-(4-pyridinyl)-;Pyrazolo[1,5-a]pyrimidine,6-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-(4-pyridinyl)-;4-(2-(4-(3-(Pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenoxy)ethyl)morpholine;4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl]phenoxy}ethyl)morpholine;pyrazolo[1,5-a]pyrimidine,6-(4-(2-(4-morpholinyl)ethoxy)phenyl)-3-(4-pyridinyl)-;dorsomorphin (6K1);BDBM5416;SCHEMBL2059673;AKOS032961561;PD055924;3-(4-Pyridinyl)-6-[4-(2-morpholinoethoxy)phenyl]pyrazolo[1,5-a]pyrimidine

Suppliers and Price of 4-[2-[4-(3-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-[2-[4-(3-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:401.18517499
Heavy Atom Count:30
Complexity:518

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COCCN1CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3

Technology Process of 4-[2-[4-(3-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine

There total 9 articles about 4-[2-[4-(3-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 3647-69-6
4-(2-chloroethyl)morpholine hydrochride

: 515880-87-2
6-(4-hydroxyphenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine

: 597544-21-3
4-(2-(4-(3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenoxy)ethyl)morpholine

Guidance literature:: With caesium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 60 ℃; for 24h;
DOI:10.1016/j.bmcl.2008.06.052

Reference yield:

: 216661-58-4
3-(pyridin-4-yl)-6-(4-methoxyphenyl)-pyrazolo(1,5-A)pyrimidine

: 597544-21-3
4-(2-(4-(3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenoxy)ethyl)morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / HBr; AcOH / Heating

2: NaH / dimethylformamide / 50 °C

With hydrogen bromide; sodium hydride; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00827-2