4-(((3S,4S)-1-(5-cyanothiazol-2-yl)-4-ethylpyrrolidin-3-yl)amino)-6-(6-((2-methoxyacetamido)methyl)pyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide

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Chemical Name:4-(((3S,4S)-1-(5-cyanothiazol-2-yl)-4-ethylpyrrolidin-3-yl)amino)-6-(6-((2-methoxyacetamido)methyl)pyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide
CAS No.:1400579-56-7
Molecular Formula:C₂₇H₂₉N₉O₃S
Molecular Weight:559.652
Hs Code.:

4-(((3S,4S)-1-(5-cyanothiazol-2-yl)-4-ethylpyrrolidin-3-yl)amino)-6-(6-((2-methoxyacetamido)methyl)pyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide

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Chemical Property of 4-(((3S,4S)-1-(5-cyanothiazol-2-yl)-4-ethylpyrrolidin-3-yl)amino)-6-(6-((2-methoxyacetamido)methyl)pyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide

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Technology Process of 4-(((3S,4S)-1-(5-cyanothiazol-2-yl)-4-ethylpyrrolidin-3-yl)amino)-6-(6-((2-methoxyacetamido)methyl)pyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide

There total 7 articles about 4-(((3S,4S)-1-(5-cyanothiazol-2-yl)-4-ethylpyrrolidin-3-yl)amino)-6-(6-((2-methoxyacetamido)methyl)pyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 4-(((3S,4S)-4-ethylpyrrolidin-3-yl)amino)-6-(6-((2-methoxyacetamido)methyl)pyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide dihydroiodide

: 51640-36-9
2-chloro-1,3-thiazole-5-carbonitrile

: 1400579-56-7
4-(((3S,4S)-1-(5-cyanothiazol-2-yl)-4-ethylpyrrolidin-3-yl)amino)-6-(6-((2-methoxyacetamido)methyl)pyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ISOPROPYLAMIDE; at 100 ℃; for 2h;

Reference yield:

: 88139-91-7
(5-bromopyridin-2-yl)methanol

: 1400579-56-7
4-(((3S,4S)-1-(5-cyanothiazol-2-yl)-4-ethylpyrrolidin-3-yl)amino)-6-(6-((2-methoxyacetamido)methyl)pyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,1'-azodicarbonyl-dipiperidine; triphenylphosphine / tetrahydrofuran / 20 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 70 °C / Inert atmosphere

3.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ISOPROPYLAMIDE / 1 h / 90 °C

4.1: hydrazine hydrate / ethanol; tetrahydrofuran / 3.17 h / 70 °C

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

6.1: trimethylsilyl iodide / acetonitrile / 6 h / 0 - 20 °C

6.2: 0.5 h / 0 °C

7.1: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 2 h / 100 °C

With potassium phosphate; trimethylsilyl iodide; potassium acetate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; ethanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide; acetonitrile; 3.1: Suzuki Coupling;

Reference yield:

: 871728-43-7
2-((5-bromopyridin-2-yl)methyl)isoindoline-1,3-dione

: 1400579-56-7
4-(((3S,4S)-1-(5-cyanothiazol-2-yl)-4-ethylpyrrolidin-3-yl)amino)-6-(6-((2-methoxyacetamido)methyl)pyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 70 °C / Inert atmosphere

2.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ISOPROPYLAMIDE / 1 h / 90 °C

3.1: hydrazine hydrate / ethanol; tetrahydrofuran / 3.17 h / 70 °C

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

5.1: trimethylsilyl iodide / acetonitrile / 6 h / 0 - 20 °C

5.2: 0.5 h / 0 °C

6.1: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 2 h / 100 °C

With potassium phosphate; trimethylsilyl iodide; potassium acetate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; ethanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide; acetonitrile; 2.1: Suzuki Coupling;