2-cyano-3-(3-chloro-4-fluorophenyl)aminoacrylic acid ethyl ester

Base Information

• Chemical Name: 2-cyano-3-(3-chloro-4-fluorophenyl)aminoacrylic acid ethyl ester
• CAS No.: 218457-28-4
• Molecular Formula: C₁₂H₁₀ClFN₂O₂
• Molecular Weight: 268.675
• Mol file: 218457-28-4.mol

Synonyms:

Chemical Property of 2-cyano-3-(3-chloro-4-fluorophenyl)aminoacrylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyano-3-(3-chloro-4-fluorophenyl)aminoacrylic acid ethyl ester

There total 1 articles about 2-cyano-3-(3-chloro-4-fluorophenyl)aminoacrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-4-fluorophenylamine (367-21-5) + ethyl (ethoxymethylene)cyanoacetate (94-05-3,42466-69-3) → 2-cyano-3-(3-chloro-4-fluorophenyl)aminoacrylic acid ethyl ester (218457-28-4)

Guidance literature:

at 120 ℃; Microwave irradiation; Neat (no solvent);

DOI:10.1080/00397910902906503

Reference yield: 75.6%

2-cyano-3-(3-chloro-4-fluorophenyl)aminoacrylic acid ethyl ester (218457-28-4) → 6-fluoro-7-chloro-4-quinolone-3-carbonitrile (61338-37-2,947340-01-4)

Guidance literature:

In diphenylether; at 210 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1080/00397910902906503

upstream raw materials:

3-chloro-4-fluorophenylamine

ethyl (ethoxymethylene)cyanoacetate

Downstream raw materials:

6-fluoro-7-chloro-4-quinolone-3-carbonitrile