Technology Process of N-acetyl-2-(2-bromoethoxy)-5-fluorophenylglycine
There total 1 articles about N-acetyl-2-(2-bromoethoxy)-5-fluorophenylglycine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methanesulfonic acid;
for 18h;
Yield given;
Ambient temperature;
DOI:10.1021/jo00392a017
- Guidance literature:
-
Multi-step reaction with 6 steps
1: acetic anhydride / dimethylformamide / 20 °C / 1.) 20 deg C, 2.) 50 deg C
2: 3 N NaOH / H2O / 2 h / Heating
3: 88 percent / formic acid, concd. HCl / H2O / 6 h / Heating
4: 73 percent / thionyl chloride / methanol
5: 36 percent / α-chymotrypsin / H2O; aq. HCl; NaCl / 60 h / 20 °C
6: 61 percent / acetic acid / 1.) RT, 24 h; 2.) 90 deg C, 3 h
With
hydrogenchloride; sodium hydroxide; formic acid; thionyl chloride; acetic anhydride; α-chymotrypsin;
In
hydrogenchloride; methanol; water; acetic acid; N,N-dimethyl-formamide; sodium chloride;
DOI:10.1021/jo00392a017
