cis-2-heptyl-5-butylpyrrolidine

Base Information

• Chemical Name: cis-2-heptyl-5-butylpyrrolidine
• CAS No.: 95587-05-6
• Molecular Formula: C₁₅H₃₁N
• Molecular Weight: 225.418
• Mol file: 95587-05-6.mol

Synonyms:

Chemical Property of cis-2-heptyl-5-butylpyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-2-heptyl-5-butylpyrrolidine

There total 29 articles about cis-2-heptyl-5-butylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(R)-2-((2R,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-2-phenyl-ethanol (112020-15-2) → cis-2-heptyl-5-butylpyrrolidine (95587-05-6,71732-80-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 12h;

DOI:10.1016/S0040-4020(01)81697-5

Reference yield: 90.0%

(5S)-2-butyl-5-heptyl-5-pyrroline (95513-38-5) → cis-2-heptyl-5-butylpyrrolidine (95587-05-6,71732-80-4)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; under 2844.3 Torr;

DOI:10.1021/jo00208a016

Reference yield:

(S)-1-Benzyl-5-butyl-2-heptyl-3,4-dihydro-2H-pyrrolium; chloride → cis-2-heptyl-5-butylpyrrolidine (95587-05-6,71732-80-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 2844.3 Torr; Yield given;

DOI:10.1021/jo00208a016

upstream raw materials:

n-butyl magnesium bromide

1-Bromoheptane

2-cyano-5-oxazolopyrrolidine

(R)-2-((2R,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-2-phenyl-ethanol

Downstream raw materials:

cis-2-heptyl-5-butyl-1-benzyl pyrrolidine

((2R,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-phenyl-methanone

Refernces

• 1、 Dübon, Pierre,Farwick, Andreas,Helmchen, Günter. "Enantioselective syntheses of 2-substituted pyrrolidines from allylamines by domino hydroformylation-condensation: Short syntheses of (S)-nicotine and the alkaloid 225C". body text. p. 1413 - 1416. Retrieved 2009/10/23.
• 2、 Shiosaki, Kazumi,Rapoport, Henry. "α-Amino Acids as Chiral Educts for Asymmetric Products. Chirospecific Syntheses of the 5-Butyl-2-heptylpyrrolidines from Glutamic Acid". . p. 1229 - 1239. Retrieved 2007/10/02.