N-Methyl Moxifloxacin

Base Information

• Chemical Name: N-Methyl Moxifloxacin
• CAS No.: 721970-37-2
• Molecular Formula: C₂₂H₂₆FN₃O₄
• Molecular Weight: 415.465
• Mol file: 721970-37-2.mol

Synonyms:

Chemical Property of N-Methyl Moxifloxacin

Chemical Property:

• Melting Point: >166 ° C (dec.)
• Boiling Point: 616.5±55.0 °C(Predicted)
• PKA: 6.43±0.50(Predicted)
• Density: 1.384±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Sparingly, Sonicated), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

N-MethylMoxifloxacinHydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Methyl Moxifloxacin is an impurity of impurities in moxifloxacin (M745000). Moxifloxacin is a fluorinated quinolone antibacterial.

Technology Process of N-Methyl Moxifloxacin

There total 6 articles about N-Methyl Moxifloxacin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + moxifloxacin (151096-09-2,1346747-14-5,158060-78-7,195154-07-5,268545-13-7,354812-41-2) → N-methylmoxifloxacin (721970-37-2)

Guidance literature:

With formic acid; for 4h; Reflux;

Reference yield:

C23H28FN3O4 (1420107-30-7) → N-methylmoxifloxacin (721970-37-2)

Guidance literature:

C₂₃H₂₈FN₃O₄; With sodium hydroxide; In methanol; water; at 20 ℃; for 1h;

With hydrogenchloride; In methanol; water; pH=8-9;

Reference yield:

moxifloxacin p-toluenesulfonate → N-methylmoxifloxacin (721970-37-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / isopropyl alcohol; water; dichloromethane / 1 h / 30 - 35 °C

2.1: potassium carbonate / methanol / 0 - 20 °C

3.1: sodium hydroxide / methanol; water / 1 h / 20 °C

3.2: pH 8-9

With sodium hydrogencarbonate; potassium carbonate; sodium hydroxide; In methanol; dichloromethane; water; isopropyl alcohol;

upstream raw materials:

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

(1S,6S)-2,8-diazabicyclo[4.3.0]nonane

C₂₃H₂₈FN₃O₄

moxifloxacin

Refernces

• 1、 -. "N-methylmoxifloxacin aldehyde thiosemicarbazone derivative, and preparation method and application thereof". Paragraph 0033; 0034; 0035; 0036; 0037; 0038. . Retrieved 2017/08/29.
• 2、 -. "MOXIFLOXACIN HYDROCHLORIDE COMPOUNDS AND INTERMEDIATES AND METHODS FOR MAKING SAME". . . Retrieved 2013/03/26.