Minoxidil Impurity D

Base Information

• Chemical Name: Minoxidil Impurity D
• CAS No.: 75105-16-7
• Molecular Formula: C₁₁H₁₂N₄O₄S
• Molecular Weight: 296.307
• UNII: 2V3BWH43UP
• Mol file: 75105-16-7.mol

Synonyms:Minoxidil Impurity D;75105-16-7;2,6-Diamino-4-pyrimidinyl p-Toluenesulfonate 3-Oxide;(6-amino-1-hydroxy-2-iminopyrimidin-4-yl) 4-methylbenzenesulfonate;2V3BWH43UP;SCHEMBL9804556;6-Tosyloxy-2,4-diaminopyrimidine 3-oxide;6-amino-2-imino-4-(tosyloxy)-2,3-dihydropyrimidine 1-oxide;4-Pyrimidinol, 2,6-diamino-, 4-(4-methylbenzenesulfonate) 1-oxide;6-[[(4-methylphenyl)sulfonyl]oxy]pyrimidine-2,4-diamine 3-oxide;4-Pyrimidinol, 2,6-diamino-, 4-methylbenzenesulfonate (ester), 1-oxide

Chemical Property of Minoxidil Impurity D

Chemical Property:

• XLogP3: 0.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 296.05792605
• Heavy Atom Count: 20
• Complexity: 556

Purity/Quality:

99%min. ^*data from raw suppliers

2,6-Diamino-4-pyrimidinyl p-Toluenesulfonate 3-Oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)OC2=NC(=N)N(C(=C2)N)O
• Uses: Minoxidil IMpurity D is used in the preparation of a hypotensive drug. It is an intermediate in the preparation of Minoxidil (M354000). 2,6-Diamino-4-pyrimidinyl p-Toluenesulfonate 3-Oxide (Minoxidil EP Impurity D) is used in the preparation of a hypotensive drug. It is an intermediate in the preparation of Minoxidil (M354000).

Technology Process of Minoxidil Impurity D

There total 1 articles about Minoxidil Impurity D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(p-tolylsulfonyloxy)-2,4-diaminopyrimidine → 6-tosyloxy-2,4-diaminopyrimidine-3-oxide (75105-16-7)

Guidance literature:

With monoperoxyphthalic acid magnesium salt hexahydrate; In methanol; water; acetone;

Refernces

• 1、 -. "Method for the preparation of a therapeutically active compound". . . Retrieved 2008/06/13.