tert-butyl 5-formylpicolinate

Base Information

• Chemical Name: tert-butyl 5-formylpicolinate
• CAS No.: 943844-15-3
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229
• Mol file: 943844-15-3.mol

Synonyms:

Chemical Property of tert-butyl 5-formylpicolinate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 5-formylpicolinate

There total 3 articles about tert-butyl 5-formylpicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 5-(1,2-dihydroxyethyl)picolinate → tert-butyl 5-formylpicolinate (943844-15-3)

Guidance literature:

With sodium periodate; In tetrahydrofuran; water; at 0 ℃; for 16h; Inert atmosphere;

Reference yield:

tert-butyl 5-bromopyridine-2-carboxylate (845306-08-3) → tert-butyl 5-formylpicolinate (943844-15-3)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 24 h / 100 °C / Sealed tube; Inert atmosphere

2: AD-mix-beta / water; tert-butyl alcohol / 0 °C

3: sodium periodate / tetrahydrofuran; water / 16 h / 0 °C / Inert atmosphere

With sodium periodate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

tert-butyl 5-vinylpicolinate → tert-butyl 5-formylpicolinate (943844-15-3)

Guidance literature:

Multi-step reaction with 2 steps

1: AD-mix-beta / water; tert-butyl alcohol / 0 °C

2: sodium periodate / tetrahydrofuran; water / 16 h / 0 °C / Inert atmosphere

With sodium periodate; In tetrahydrofuran; water; tert-butyl alcohol;

upstream raw materials:

tert-butyl 5-bromopyridine-2-carboxylate

Refernces