Fevipiprant

Base Information

Chemical Name:Fevipiprant
CAS No.:872365-14-5
Molecular Formula:C₁₉H₁₇F₃N₂O₄S
Molecular Weight:426.416
Hs Code.:2933998090
Mol file:872365-14-5.mol

Synonyms:

Suppliers and Price of Fevipiprant

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Fevipiprant
1mg
$ 65.00

DC Chemicals
Fevipiprant >98%
100 mg
$ 600.00

DC Chemicals
Fevipiprant >98%
1 g
$ 2200.00

Crysdot
Fevipiprant 97%
10mg
$ 63.00

Crysdot
Fevipiprant 97%
5mg
$ 42.00

Crysdot
Fevipiprant 97%
25mg
$ 126.00

Crysdot
Fevipiprant 97%
50mg
$ 168.00

Crysdot
Fevipiprant 97%
100mg
$ 308.00

ChemScene
Fevipiprant 99.63%
200mg
$ 888.00

ChemScene
Fevipiprant 99.63%
25mg
$ 216.00

Total 51 raw suppliers

Chemical Property of Fevipiprant

Chemical Property:

Boiling Point:637.6±55.0 °C(Predicted)
PKA:3.33±0.30(Predicted)
Density:1.44±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Fevipiprant ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Fevipiprant is used in the oral treatment of asthma and has been successful in targeting severe eosinophilic asthma.Fevipiprant is a novel oral prostaglandin D2 receptor 2 (DP2; known as CRTh2) antagonist and currently in development for the treatment of severe asthma and atopic dermatitis.

Technology Process of Fevipiprant

There total 43 articles about Fevipiprant which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: methyl 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,2-b]pyridin-3-yl)-4-(methylperoxy)but-3-ynoate

: 872365-14-5
2-[2-methyl-1-[[4-methylsulfonyl-2-(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridine-3-yl]acetic acid

Guidance literature:: methyl 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,2-b]pyridin-3-yl)-4-(methylperoxy)but-3-ynoate; With acetic acid; at 20 - 30 ℃; for 0.5h;

With hydrogenchloride; at 20 - 105 ℃; for 4h;

Reference yield: 82.0%

: 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-oxoacetic acid

: 872365-14-5
2-[2-methyl-1-[[4-methylsulfonyl-2-(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridine-3-yl]acetic acid

Guidance literature:: With triethylsilane; trifluoroacetic acid; at 0 - 50 ℃; for 4.5h; Inert atmosphere;

Reference yield: 75.0%

: methyl 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate

: 872365-14-5
2-[2-methyl-1-[[4-methylsulfonyl-2-(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridine-3-yl]acetic acid

Guidance literature:: methyl 2-(1-{[4-methanesulfonyl-2-(trifluoromethyl)phenyl]methyl}-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate; With sodium hydroxide; In water; at 50 ℃; for 1h;

With sulfuric acid; In n-heptane; water; at 70 - 80 ℃; pH=4 - 4.5;
DOI:10.1002/ejoc.202100686